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• W1985377557 abstract "The signal transducing integral membrane protein, MecR1 helps initiate the expression of the antibiotic-resistant gene mecA, which encodes the penicillin-binding protein 2a. MecA participates in the β-lactam resistance of methicillin-resistant Staphylococcus aureus (MRSA). Blocking the MecR1 regulatory pathway may be a novel strategy to combat MRSA. In this study, we introduced an antisense phosphothioate oligodeoxynucleotide (PS-ODN) targeting MecR1 mRNA into the MRSA strain WHO-2, which led to a significant reduction of both MecR1 and PBP2a mRNAs in a concentration-dependent manner. Consequently, the susceptibility of S. aureus WHO-2 to the β-lactam antibiotic oxacillin was restored significantly. Our results indicate that blocking the mecR1-mecI-mecA signaling pathway via an antisense approach might be a viable strategy to restore the susceptibility of MRSA to the existing β-lactam antibiotics." @default.
• W1985377557 created "2016-06-24" @default.
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• W1985377557 date "2006-08-01" @default.
• W1985377557 modified "2023-09-22" @default.
• W1985377557 title "Restoration of Oxacillin Susceptibility in Methicillin-Resistant<i>Staphylococcus aureus</i>by Blocking the MecR1-Mediated Signaling Pathway" @default.
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• W1985377557 doi "https://doi.org/10.1179/joc.2006.18.4.360" @default.
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