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• W1985384141 abstract "The taxanes paclitaxel and docetaxel show good activity in the management of advanced ovarian cancer when used in conjunction with platinum agents. Accumulating evidence from clinical studies, particularly the latest results from the phase III comparative SCOTROC study, indicates that the two drugs confer similar rates of tumour response and survival in women with this condition. However, it is clear that paclitaxel and docetaxel differ in their tolerability profiles and in other respects, and cannot be regarded as directly equivalent drugs. In particular, paclitaxel is associated with significant neurotoxicity; peripheral neuropathy has also been reported with docetaxel, but to a lesser extent. Neutropenia appears more prevalent with docetaxel than with paclitaxel, although clinical trial data show that this adverse effect is manageable and need not compromise dose delivery. Docetaxel is also associated with potential benefits accruing from shorter infusion times and lack of need for premedication with intravenous histamine H1 and H2 antagonists. Emerging quality of life data are expected to shed further light on the overall benefit of chemotherapy in women with advanced ovarian cancer in general, and on taxane−platinum combinations in particular." @default.
• W1985384141 created "2016-06-24" @default.
• W1985384141 creator A5056565799 @default.
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• W1985384141 date "2003-12-01" @default.
• W1985384141 modified "2023-10-06" @default.
• W1985384141 title "The taxanes: toxicity and quality of life considerations in advanced ovarian cancer" @default.
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• W1985384141 doi "https://doi.org/10.1038/sj.bjc.6601496" @default.
• W1985384141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2750618" @default.
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• W1985384141 hasPublicationYear "2003" @default.
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