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- W1985387345 abstract "The leukotactic responsiveness of human peripheral blood monocytes is regulated by the cell-directed inhibitor of monocyte leukotaxis, CDI-MLx. Normal peripheral blood mononuclear cells elaborated CDI-MLx in vitro in response to soluble and cell-associated antigens; concanavalin A and pokeweed mitogen induced production of the inhibitor while phytohemagglutinin and staphylococcal protein A were without effect. By erythrocyte rosetting and immunoadherence, the CDI-producing cell had the phenotype, E-rosette+, OKM1+, and Leu 7+, and thus appeared related to natural killer cells. PBMC and plasma CDI-MLx had similar molecular weights (230,000) and showed similar heterogeneity on chromatofocusing with peaks of activity at pH 5.8 and 5.25. CDI-MLx was immunologically distinct from immunoglobulins, did not inactivate preformed leukotaxins, and was distinct from other lymphokines known to modulate monocyte locomotion." @default.
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- W1985387345 date "1986-01-01" @default.
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- W1985387345 title "Natural killer-like cells produce the cell-directed inhibitor of monocyte leukotaxis, CDI-MLx, in vitro" @default.
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- W1985387345 doi "https://doi.org/10.1016/0008-8749(86)90376-x" @default.
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