FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985388043> ?p ?o ?g. }

• W1985388043 endingPage "29143" @default.
• W1985388043 startingPage "29130" @default.
• W1985388043 abstract "Stargazer mice fail to express the gamma2 isoform of transmembrane alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptor regulatory proteins that has been shown to be absolutely required for the trafficking and synaptic targeting of excitatory AMPA receptors in adult murine cerebellar granule cells. Here we show that 30 +/- 6% fewer inhibitory gamma-aminobutyric acid, type A (GABA(A)), receptors were expressed in adult stargazer cerebellum compared with controls because of a specific loss of GABA(A) receptor expression in the cerebellar granule cell layer. Radioligand binding assays allied to in situ immunogold-EM analysis and furosemide-sensitive tonic current estimates revealed that expression of the extrasynaptic (alpha6betaxdelta) alpha6-containing GABA(A) receptor were markedly and selectively reduced in stargazer. These observations were compatible with a marked reduction in expression of GABA(A) receptor alpha6, delta (mature cerebellar granule cell-specific proteins), and beta3 subunit expression in stargazer. The subunit composition of the residual alpha6-containing GABA(A) receptors was unaffected by the stargazer mutation. However, we did find evidence of an approximately 4-fold up-regulation of alpha1betadelta receptors that may compensate for the loss of alpha6-containing GABA(A) receptors. PCR analysis identified a dramatic reduction in the steady-state level of alpha6 mRNA, compatible with alpha6 being the primary target of the stargazer mutation-mediated GABA(A) receptor abnormalities. We propose that some aspects of assembly, trafficking, targeting, and/or expression of extrasynaptic alpha6-containing GABA(A) receptors in cerebellar granule cells are selectively regulated by AMPA receptor-mediated signaling." @default.
• W1985388043 created "2016-06-24" @default.
• W1985388043 creator A5006625044 @default.
• W1985388043 creator A5015018111 @default.
• W1985388043 creator A5019616733 @default.
• W1985388043 creator A5021253585 @default.
• W1985388043 creator A5023046329 @default.
• W1985388043 creator A5023597751 @default.
• W1985388043 creator A5037061644 @default.
• W1985388043 creator A5047590016 @default.
• W1985388043 creator A5087192429 @default.
• W1985388043 creator A5089382389 @default.
• W1985388043 date "2007-10-01" @default.
• W1985388043 modified "2023-09-27" @default.
• W1985388043 title "GABAA α6-Containing Receptors Are Selectively Compromised in Cerebellar Granule Cells of the Ataxic Mouse, Stargazer" @default.
• W1985388043 cites W1493326255 @default.
• W1985388043 cites W1548603509 @default.
• W1985388043 cites W1550227666 @default.
• W1985388043 cites W1551663317 @default.
• W1985388043 cites W1684501056 @default.
• W1985388043 cites W1775749144 @default.
• W1985388043 cites W1932887997 @default.
• W1985388043 cites W1947066063 @default.
• W1985388043 cites W1964659923 @default.
• W1985388043 cites W1991592422 @default.
• W1985388043 cites W1996353639 @default.
• W1985388043 cites W2000337551 @default.
• W1985388043 cites W2008344134 @default.
• W1985388043 cites W2019043248 @default.
• W1985388043 cites W2019923712 @default.
• W1985388043 cites W2028885914 @default.
• W1985388043 cites W2029972861 @default.
• W1985388043 cites W2037144165 @default.
• W1985388043 cites W2049227633 @default.
• W1985388043 cites W2061920760 @default.
• W1985388043 cites W2067120553 @default.
• W1985388043 cites W2067380913 @default.
• W1985388043 cites W2072962057 @default.
• W1985388043 cites W2099762599 @default.
• W1985388043 cites W2113371568 @default.
• W1985388043 cites W2113520396 @default.
• W1985388043 cites W2113971423 @default.
• W1985388043 cites W2125277337 @default.
• W1985388043 cites W2131993013 @default.
• W1985388043 cites W2135382901 @default.
• W1985388043 cites W2139503851 @default.
• W1985388043 cites W2143454458 @default.
• W1985388043 cites W2146332920 @default.
• W1985388043 cites W2148785631 @default.
• W1985388043 cites W2161025366 @default.
• W1985388043 cites W2166223973 @default.
• W1985388043 cites W2168384606 @default.
• W1985388043 cites W2342621347 @default.
• W1985388043 cites W4300338236 @default.
• W1985388043 cites W4317524245 @default.
• W1985388043 cites W4317524510 @default.
• W1985388043 cites W4317922783 @default.
• W1985388043 doi "https://doi.org/10.1074/jbc.m700111200" @default.
• W1985388043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2974090" @default.
• W1985388043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17646167" @default.
• W1985388043 hasPublicationYear "2007" @default.
• W1985388043 type Work @default.
• W1985388043 sameAs 1985388043 @default.
• W1985388043 citedByCount "22" @default.
• W1985388043 countsByYear W19853880432012 @default.
• W1985388043 countsByYear W19853880432013 @default.
• W1985388043 countsByYear W19853880432014 @default.
• W1985388043 countsByYear W19853880432015 @default.
• W1985388043 countsByYear W19853880432016 @default.
• W1985388043 countsByYear W19853880432019 @default.
• W1985388043 countsByYear W19853880432021 @default.
• W1985388043 countsByYear W19853880432022 @default.
• W1985388043 crossrefType "journal-article" @default.
• W1985388043 hasAuthorship W1985388043A5006625044 @default.
• W1985388043 hasAuthorship W1985388043A5015018111 @default.
• W1985388043 hasAuthorship W1985388043A5019616733 @default.
• W1985388043 hasAuthorship W1985388043A5021253585 @default.
• W1985388043 hasAuthorship W1985388043A5023046329 @default.
• W1985388043 hasAuthorship W1985388043A5023597751 @default.
• W1985388043 hasAuthorship W1985388043A5037061644 @default.
• W1985388043 hasAuthorship W1985388043A5047590016 @default.
• W1985388043 hasAuthorship W1985388043A5087192429 @default.
• W1985388043 hasAuthorship W1985388043A5089382389 @default.
• W1985388043 hasBestOaLocation W19853880431 @default.
• W1985388043 hasConcept C126322002 @default.
• W1985388043 hasConcept C134018914 @default.
• W1985388043 hasConcept C148762608 @default.
• W1985388043 hasConcept C160268369 @default.
• W1985388043 hasConcept C168258287 @default.
• W1985388043 hasConcept C170493617 @default.
• W1985388043 hasConcept C185592680 @default.
• W1985388043 hasConcept C2776464000 @default.
• W1985388043 hasConcept C2778888523 @default.
• W1985388043 hasConcept C2779652256 @default.
• W1985388043 hasConcept C55493867 @default.
• W1985388043 hasConcept C61174792 @default.
• W1985388043 hasConcept C71924100 @default.
• W1985388043 hasConcept C86803240 @default.

• next