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• W1985391904 endingPage "623" @default.
• W1985391904 startingPage "617" @default.
• W1985391904 abstract "Osteoarthritis (OA) is a degenerative joint disease in which focal cartilage destruction is one of the primary features. The present study aims to evaluate the effect of a Centella asiatica fraction on in vitro and in vivo cartilage degradation. Bovine cartilage explants and bovine chondrocytes cultured in alginate were stimulated with IL-1β in the presence or absence of different concentrations (2, 5 and 10 μg/ml) of a standardized Centella asiatica triterpenes (CAT) fraction. The CAT fraction inhibited the IL-1β-induced proteoglycan (PG) release and nitric oxide (NO) production by cartilage explants in a dose-dependent manner. The IL-1β-induced reduction in PG synthesis and proliferation of chondrocytes cultured in alginate were counteracted by the CAT fraction at a concentration of 10 μg/ml. In a zymosan-induced acute arthritis model, the CAT fraction inhibited PG depletion without modulating joint swelling and inflammatory cell infiltration. In conclusion, the present study demonstrated for the first time that the tested Centella asiatica fraction was able to inhibit the zymosan-induced cartilage degradation in vivo without affecting the zymosan-induced inflammatory cell infiltration and joint swelling. The in vitro data indicate that the cartilage protective activity might at least partially be induced by the inhibition of NO production. The overall results indicate a possible disease modifying osteoarthritic activity of the Centella asiatica fraction." @default.
• W1985391904 created "2016-06-24" @default.
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• W1985391904 creator A5050218189 @default.
• W1985391904 creator A5090930450 @default.
• W1985391904 date "2009-06-01" @default.
• W1985391904 modified "2023-09-24" @default.
• W1985391904 title "<i>In Vitro</i>and<i>In Vivo</i>Modulation of Cartilage Degradation by a Standardized<i>Centella asiatica</i>Fraction" @default.
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• W1985391904 doi "https://doi.org/10.3181/0810-rm-298" @default.
• W1985391904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19307458" @default.
• W1985391904 hasPublicationYear "2009" @default.
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