FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985405118> ?p ?o ?g. }

• W1985405118 endingPage "2335" @default.
• W1985405118 startingPage "2324" @default.
• W1985405118 abstract "Notch signaling deregulation is linked to the onset of several tumors including T-cell acute lymphoblastic leukemia (T-ALL). Deregulated microRNA (miRNA) expression is also associated with several cancers, including leukemias. However, the transcriptional regulators of miRNAs, as well as the relationships between Notch signaling and miRNA deregulation, are poorly understood. To identify miRNAs regulated by Notch pathway, we performed microarray-based miRNA profiling of several Notch-expressing T-ALL models. Among seven miRNAs, consistently regulated by overexpressing or silencing Notch3, we focused our attention on miR-223, whose putative promoter analysis revealed a conserved RBPjk binding site, which was nested to an NF-kB consensus. Luciferase and chromatin immunoprecipitation assays on the promoter region of miR-223 show that both Notch and NF-kB are novel coregulatory signals of miR-223 expression, being able to activate cooperatively the transcriptional activity of miR-223 promoter. Notably, the Notch-mediated activation of miR-223 represses the tumor suppressor FBXW7 in T-ALL cell lines. Moreover, we observed the inverse correlation of miR-223 and FBXW7 expression in a panel of T-ALL patient-derived xenografts. Finally, we show that miR-223 inhibition prevents T-ALL resistance to γ-secretase inhibitor (GSI) treatment, suggesting that miR-223 could be involved in GSI sensitivity and its inhibition may be exploited in target therapy protocols." @default.
• W1985405118 created "2016-06-24" @default.
• W1985405118 creator A5004885916 @default.
• W1985405118 creator A5012369463 @default.
• W1985405118 creator A5013703740 @default.
• W1985405118 creator A5014871098 @default.
• W1985405118 creator A5015680218 @default.
• W1985405118 creator A5026589555 @default.
• W1985405118 creator A5035598492 @default.
• W1985405118 creator A5037100565 @default.
• W1985405118 creator A5047735457 @default.
• W1985405118 creator A5062202188 @default.
• W1985405118 creator A5068216029 @default.
• W1985405118 creator A5069849980 @default.
• W1985405118 creator A5072077714 @default.
• W1985405118 creator A5085045959 @default.
• W1985405118 creator A5087706646 @default.
• W1985405118 date "2014-04-14" @default.
• W1985405118 modified "2023-10-16" @default.
• W1985405118 title "Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia" @default.
• W1985405118 cites W1648301895 @default.
• W1985405118 cites W1966218963 @default.
• W1985405118 cites W1970140374 @default.
• W1985405118 cites W1977376661 @default.
• W1985405118 cites W1983614908 @default.
• W1985405118 cites W1985234929 @default.
• W1985405118 cites W1991021907 @default.
• W1985405118 cites W1996441871 @default.
• W1985405118 cites W1999547931 @default.
• W1985405118 cites W2000589976 @default.
• W1985405118 cites W2009415758 @default.
• W1985405118 cites W2013757644 @default.
• W1985405118 cites W2017719081 @default.
• W1985405118 cites W2018527149 @default.
• W1985405118 cites W2021522747 @default.
• W1985405118 cites W2025439246 @default.
• W1985405118 cites W2025462312 @default.
• W1985405118 cites W2025560247 @default.
• W1985405118 cites W2025748388 @default.
• W1985405118 cites W2029620430 @default.
• W1985405118 cites W2030367937 @default.
• W1985405118 cites W2032095580 @default.
• W1985405118 cites W2032534720 @default.
• W1985405118 cites W2033430047 @default.
• W1985405118 cites W2033801528 @default.
• W1985405118 cites W2040134256 @default.
• W1985405118 cites W2041175983 @default.
• W1985405118 cites W2044724807 @default.
• W1985405118 cites W2045998598 @default.
• W1985405118 cites W2049229611 @default.
• W1985405118 cites W2050354953 @default.
• W1985405118 cites W2058213712 @default.
• W1985405118 cites W2059382687 @default.
• W1985405118 cites W2062625397 @default.
• W1985405118 cites W2062947546 @default.
• W1985405118 cites W2073745960 @default.
• W1985405118 cites W2077489715 @default.
• W1985405118 cites W2081433449 @default.
• W1985405118 cites W2083458934 @default.
• W1985405118 cites W2084743841 @default.
• W1985405118 cites W2091129822 @default.
• W1985405118 cites W2093364931 @default.
• W1985405118 cites W2097938836 @default.
• W1985405118 cites W2104039084 @default.
• W1985405118 cites W2108822341 @default.
• W1985405118 cites W2110307583 @default.
• W1985405118 cites W2112357436 @default.
• W1985405118 cites W2116965161 @default.
• W1985405118 cites W2122769325 @default.
• W1985405118 cites W2126247355 @default.
• W1985405118 cites W2130979840 @default.
• W1985405118 cites W2132113444 @default.
• W1985405118 cites W2133440148 @default.
• W1985405118 cites W2135763107 @default.
• W1985405118 cites W2137116933 @default.
• W1985405118 cites W2152244674 @default.
• W1985405118 cites W2154861644 @default.
• W1985405118 cites W2165208287 @default.
• W1985405118 cites W2170400030 @default.
• W1985405118 doi "https://doi.org/10.1038/leu.2014.133" @default.
• W1985405118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24727676" @default.
• W1985405118 hasPublicationYear "2014" @default.
• W1985405118 type Work @default.
• W1985405118 sameAs 1985405118 @default.
• W1985405118 citedByCount "139" @default.
• W1985405118 countsByYear W19854051182014 @default.
• W1985405118 countsByYear W19854051182015 @default.
• W1985405118 countsByYear W19854051182016 @default.
• W1985405118 countsByYear W19854051182017 @default.
• W1985405118 countsByYear W19854051182018 @default.
• W1985405118 countsByYear W19854051182019 @default.
• W1985405118 countsByYear W19854051182020 @default.
• W1985405118 countsByYear W19854051182021 @default.
• W1985405118 countsByYear W19854051182022 @default.
• W1985405118 countsByYear W19854051182023 @default.
• W1985405118 crossrefType "journal-article" @default.
• W1985405118 hasAuthorship W1985405118A5004885916 @default.
• W1985405118 hasAuthorship W1985405118A5012369463 @default.

• next