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- W1985406987 abstract "Soluble oat extracts have been used successfully in a number of diet studies to lower plasma blood lipids. One of the mechanisms proposed for this reduction in lipids is the production of short-chain fatty acids in the large intestine, which, in turn, may inhibit low-density lipoprotein cholesterol synthesis, thereby limiting oxidation. Urinary excretion of malondialdehyde (MDA) is proportional to endogenous lipid peroxidation. The purpose of this report is to examine the effects of consuming oat extracts with low (1%) or high (10%) levels of soluble β-glucans on lipid peroxidation as measured by urinary malondialdehyde excretion. Twenty-four subjects with moderately elevated cholesterol levels (6.0 mmol/L) were selected for the study. A 1-week equilibration period was followed by two 5-week experimental periods during which defined diets contained the 1% or 10% oat extracts in a crossover design. Seventy-two-hr urine samples (3 × 24-hr) were collected at the end of each period. Urinary levels of MDA excreted were 10–18% of dietary MDA consumed. Consumption of either of the oat extracts resulted in highly significant reductions in urinary excretion of malondialdehyde (P < 0.0001). These data would support the hypothesis that oat extracts inhibit endogenous lipid peroxidation by reduction of MDA (a marker for fatty acid oxidation); however, because no significant differences were found in MDA excretion after subjects consumed the two levels of β-glucans, this is apparently not the responsible component. Further examination of this mechanism in the control of lipid metabolism is warranted." @default.
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- W1985406987 date "1997-09-01" @default.
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- W1985406987 title "Diets Containing Soluble Oat Extracts Reduce Urinary Malondialdehyde in Moderately Hypercholesterolemic Men and Women" @default.
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- W1985406987 doi "https://doi.org/10.1016/s0955-2863(97)00079-x" @default.
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