Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985423661> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1985423661 endingPage "65" @default.
- W1985423661 startingPage "61" @default.
- W1985423661 abstract "Objective: The aim of this study was to investigate whether the use of Naloxone (Nx) may prove effective as a prokinetic agent in a septic model in rats. Design: 100 male Swiss-Albino rats were divided in five groups. All rats were housed under standard environmental conditions and fasted for 18 hours. Group I (n = 20) underwent sham laparotomy and intraperitoneal (IP) saline injection after 24 hours, Group II (n = 20) underwent sham laparotomy and subcutaneous (SC) fentanyl injection after 24 hours, in Group III (n = 20) sepsis was induced via caecal ligation and perforation (CLP) and IP saline injection after 24 hours, Group IV (n = 20) 24 hours after CLP, SC fentanyl was given and Group V (n = 20) 24 hours after CLP, Nx was given IP. Twenty minutes after saline or drug injections 0.25 ml of charcoal suspension was given as an intragastric meal and all rats were killed 20 minutes afterwards to measure the gastrointestinal transit (GIT) %. GIT% was calculated as the percentage of the distance travelled by charcoal relative to the total length of the small intestine. Results: GIT% (mean ± SD) were 46.2 ± 9.8, 43.2 ± 9.8, 33.2 ± 9.3, 24.9 ± 4.1, 41.3 ± 8.2 in Groups I, II, III, IV and V, respectively. The mean values of Group III and Group IV were significantly lower than the other groups. The mean value of Group V was found to be similar to the mean value of Group I. Conclusion: Fentanyl enhances the decrease in GIT seen during sepsis, possibly by an increase in the active concentration or sensitization of opioid receptors. Naloxone increases GIT in sepsis. For this reason, Nx could have a potential role as a prokinetic agent in sepsis." @default.
- W1985423661 created "2016-06-24" @default.
- W1985423661 creator A5006537611 @default.
- W1985423661 creator A5009474969 @default.
- W1985423661 creator A5056727617 @default.
- W1985423661 creator A5066897417 @default.
- W1985423661 creator A5071579775 @default.
- W1985423661 creator A5078709313 @default.
- W1985423661 date "2001-04-01" @default.
- W1985423661 modified "2023-10-01" @default.
- W1985423661 title "Can naloxone be a prokinetic agent in sepsis?" @default.
- W1985423661 cites W1497506647 @default.
- W1985423661 cites W1517722308 @default.
- W1985423661 cites W1635456449 @default.
- W1985423661 cites W1963522894 @default.
- W1985423661 cites W1987755130 @default.
- W1985423661 cites W1996052504 @default.
- W1985423661 cites W2007414499 @default.
- W1985423661 cites W2009081930 @default.
- W1985423661 cites W2018269104 @default.
- W1985423661 cites W2022477506 @default.
- W1985423661 cites W2044932964 @default.
- W1985423661 cites W2059730682 @default.
- W1985423661 cites W2075322499 @default.
- W1985423661 cites W2076635491 @default.
- W1985423661 cites W2087455957 @default.
- W1985423661 cites W2143051404 @default.
- W1985423661 cites W2319289400 @default.
- W1985423661 doi "https://doi.org/10.3109/tcic.12.2.61.65" @default.
- W1985423661 hasPublicationYear "2001" @default.
- W1985423661 type Work @default.
- W1985423661 sameAs 1985423661 @default.
- W1985423661 citedByCount "1" @default.
- W1985423661 crossrefType "journal-article" @default.
- W1985423661 hasAuthorship W1985423661A5006537611 @default.
- W1985423661 hasAuthorship W1985423661A5009474969 @default.
- W1985423661 hasAuthorship W1985423661A5056727617 @default.
- W1985423661 hasAuthorship W1985423661A5066897417 @default.
- W1985423661 hasAuthorship W1985423661A5071579775 @default.
- W1985423661 hasAuthorship W1985423661A5078709313 @default.
- W1985423661 hasConcept C126322002 @default.
- W1985423661 hasConcept C141071460 @default.
- W1985423661 hasConcept C170493617 @default.
- W1985423661 hasConcept C191897082 @default.
- W1985423661 hasConcept C192562407 @default.
- W1985423661 hasConcept C2777389121 @default.
- W1985423661 hasConcept C2777397205 @default.
- W1985423661 hasConcept C2778384902 @default.
- W1985423661 hasConcept C2778456384 @default.
- W1985423661 hasConcept C2778527123 @default.
- W1985423661 hasConcept C2778750930 @default.
- W1985423661 hasConcept C2780778865 @default.
- W1985423661 hasConcept C2781063702 @default.
- W1985423661 hasConcept C2781072394 @default.
- W1985423661 hasConcept C42219234 @default.
- W1985423661 hasConcept C71924100 @default.
- W1985423661 hasConceptScore W1985423661C126322002 @default.
- W1985423661 hasConceptScore W1985423661C141071460 @default.
- W1985423661 hasConceptScore W1985423661C170493617 @default.
- W1985423661 hasConceptScore W1985423661C191897082 @default.
- W1985423661 hasConceptScore W1985423661C192562407 @default.
- W1985423661 hasConceptScore W1985423661C2777389121 @default.
- W1985423661 hasConceptScore W1985423661C2777397205 @default.
- W1985423661 hasConceptScore W1985423661C2778384902 @default.
- W1985423661 hasConceptScore W1985423661C2778456384 @default.
- W1985423661 hasConceptScore W1985423661C2778527123 @default.
- W1985423661 hasConceptScore W1985423661C2778750930 @default.
- W1985423661 hasConceptScore W1985423661C2780778865 @default.
- W1985423661 hasConceptScore W1985423661C2781063702 @default.
- W1985423661 hasConceptScore W1985423661C2781072394 @default.
- W1985423661 hasConceptScore W1985423661C42219234 @default.
- W1985423661 hasConceptScore W1985423661C71924100 @default.
- W1985423661 hasIssue "2" @default.
- W1985423661 hasLocation W19854236611 @default.
- W1985423661 hasOpenAccess W1985423661 @default.
- W1985423661 hasPrimaryLocation W19854236611 @default.
- W1985423661 hasRelatedWork W1985423661 @default.
- W1985423661 hasRelatedWork W1990546395 @default.
- W1985423661 hasRelatedWork W2019390071 @default.
- W1985423661 hasRelatedWork W2079890364 @default.
- W1985423661 hasRelatedWork W2080239242 @default.
- W1985423661 hasRelatedWork W2147130154 @default.
- W1985423661 hasRelatedWork W2333740563 @default.
- W1985423661 hasRelatedWork W2356974960 @default.
- W1985423661 hasRelatedWork W2549135832 @default.
- W1985423661 hasRelatedWork W4237505675 @default.
- W1985423661 hasVolume "12" @default.
- W1985423661 isParatext "false" @default.
- W1985423661 isRetracted "false" @default.
- W1985423661 magId "1985423661" @default.
- W1985423661 workType "article" @default.