Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985424260> ?p ?o ?g. }
- W1985424260 endingPage "900" @default.
- W1985424260 startingPage "886" @default.
- W1985424260 abstract "Several NO donor 3,4-diphenylfuroxan (=3,4-diphenyl-1,2,5-oxadiazole 2-oxide) derivatives were synthesized and tested for their COX-inhibiting activities. The products were found to be selective COX-2 inhibitors, similar to the structurally related furazans (3,4-diphenyl-1,2,5-oxadiazole), devoid of the NO release property. This behavior was confirmed by a molecular-docking study. The NO-dependent platelet anti-aggregatory and vasodilating activities of the new furoxans 5–7 were studied in vitro. These properties can be modulated by inserting an appropriate spacer between the 4-phenyl group and the furoxan ring, giving rise to new, selective COX-2 furoxan derivatives endowed with anti-aggregatory and vasodilating activities, and with potentially reduced cardiotoxicities." @default.
- W1985424260 created "2016-06-24" @default.
- W1985424260 creator A5008583952 @default.
- W1985424260 creator A5009764916 @default.
- W1985424260 creator A5026659281 @default.
- W1985424260 creator A5028202182 @default.
- W1985424260 creator A5029092499 @default.
- W1985424260 creator A5051463902 @default.
- W1985424260 creator A5062037258 @default.
- W1985424260 creator A5062208191 @default.
- W1985424260 date "2005-07-01" @default.
- W1985424260 modified "2023-10-16" @default.
- W1985424260 title "The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX-2 Endowed with Anti-Aggregatory and Vasodilating Activities" @default.
- W1985424260 cites W1676314625 @default.
- W1985424260 cites W1967225427 @default.
- W1985424260 cites W1971572370 @default.
- W1985424260 cites W1974450761 @default.
- W1985424260 cites W1979502801 @default.
- W1985424260 cites W1984422911 @default.
- W1985424260 cites W1995060832 @default.
- W1985424260 cites W2003989644 @default.
- W1985424260 cites W2004916700 @default.
- W1985424260 cites W2007737411 @default.
- W1985424260 cites W2016238479 @default.
- W1985424260 cites W2019478224 @default.
- W1985424260 cites W2024233889 @default.
- W1985424260 cites W2026294448 @default.
- W1985424260 cites W2030850720 @default.
- W1985424260 cites W2033498682 @default.
- W1985424260 cites W2041075406 @default.
- W1985424260 cites W2042071104 @default.
- W1985424260 cites W2050999963 @default.
- W1985424260 cites W2057491831 @default.
- W1985424260 cites W2059749777 @default.
- W1985424260 cites W2064747164 @default.
- W1985424260 cites W2071579644 @default.
- W1985424260 cites W2076974145 @default.
- W1985424260 cites W2078736915 @default.
- W1985424260 cites W2082276462 @default.
- W1985424260 cites W2104380573 @default.
- W1985424260 cites W2105318758 @default.
- W1985424260 cites W2121853844 @default.
- W1985424260 cites W2122199548 @default.
- W1985424260 cites W2130479394 @default.
- W1985424260 cites W2147421370 @default.
- W1985424260 cites W2166114438 @default.
- W1985424260 cites W2168402808 @default.
- W1985424260 cites W2314414569 @default.
- W1985424260 cites W2320786827 @default.
- W1985424260 cites W2951746982 @default.
- W1985424260 cites W4239908748 @default.
- W1985424260 doi "https://doi.org/10.1002/cbdv.200590065" @default.
- W1985424260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17193179" @default.
- W1985424260 hasPublicationYear "2005" @default.
- W1985424260 type Work @default.
- W1985424260 sameAs 1985424260 @default.
- W1985424260 citedByCount "34" @default.
- W1985424260 countsByYear W19854242602012 @default.
- W1985424260 countsByYear W19854242602013 @default.
- W1985424260 countsByYear W19854242602014 @default.
- W1985424260 countsByYear W19854242602015 @default.
- W1985424260 countsByYear W19854242602016 @default.
- W1985424260 countsByYear W19854242602017 @default.
- W1985424260 countsByYear W19854242602018 @default.
- W1985424260 countsByYear W19854242602019 @default.
- W1985424260 countsByYear W19854242602020 @default.
- W1985424260 countsByYear W19854242602021 @default.
- W1985424260 countsByYear W19854242602022 @default.
- W1985424260 countsByYear W19854242602023 @default.
- W1985424260 crossrefType "journal-article" @default.
- W1985424260 hasAuthorship W1985424260A5008583952 @default.
- W1985424260 hasAuthorship W1985424260A5009764916 @default.
- W1985424260 hasAuthorship W1985424260A5026659281 @default.
- W1985424260 hasAuthorship W1985424260A5028202182 @default.
- W1985424260 hasAuthorship W1985424260A5029092499 @default.
- W1985424260 hasAuthorship W1985424260A5051463902 @default.
- W1985424260 hasAuthorship W1985424260A5062037258 @default.
- W1985424260 hasAuthorship W1985424260A5062208191 @default.
- W1985424260 hasConcept C120770815 @default.
- W1985424260 hasConcept C164705383 @default.
- W1985424260 hasConcept C178790620 @default.
- W1985424260 hasConcept C185592680 @default.
- W1985424260 hasConcept C202751555 @default.
- W1985424260 hasConcept C21951064 @default.
- W1985424260 hasConcept C2776948483 @default.
- W1985424260 hasConcept C519581460 @default.
- W1985424260 hasConcept C55493867 @default.
- W1985424260 hasConcept C71240020 @default.
- W1985424260 hasConcept C71924100 @default.
- W1985424260 hasConcept C98274493 @default.
- W1985424260 hasConceptScore W1985424260C120770815 @default.
- W1985424260 hasConceptScore W1985424260C164705383 @default.
- W1985424260 hasConceptScore W1985424260C178790620 @default.
- W1985424260 hasConceptScore W1985424260C185592680 @default.
- W1985424260 hasConceptScore W1985424260C202751555 @default.
- W1985424260 hasConceptScore W1985424260C21951064 @default.
- W1985424260 hasConceptScore W1985424260C2776948483 @default.
- W1985424260 hasConceptScore W1985424260C519581460 @default.