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• W1985427864 abstract "Summary. Hepatitis B virus (HBV) genotypes B and C are most prevalent in China and genotype B is found exclusively in recombination with the pre‐C/C gene of genotype C. We investigated whether there is a difference in clinical relevance between the two genotypes sharing the same pre‐C/C gene. Thus, we determined the genotype of HBV among consecutive HBeAg‐positive patients with tailored interferon‐alpha (IFN‐ α ) therapy, and the demographic, baseline clinical characteristics and treatment results were compared between them. The median values of alanine transaminase (ALT) were 4.5 and 5.0 times the upper limit of normal ( P = 0.419), HBV‐DNA levels were 1.4 × 10 7 and 1.5 × 10 7 copies/mL ( P = 0.829), mean scores of necroinflammatory histological activity 9.8 and 10.44 ( P = 0.105) and fibrotic activity 2.64 and 2.86 ( P = 0.227) in genotype B and C patients, respectively. The end‐of‐treatment response was 42.7% and 39.0% ( P = 0.531) with mean tailored treatment months of 8.28 and 9.34 ( P = 0.160), and the sustained response 43.4% and 37.5% ( P = 0.31) at the end of a 12‐month follow‐up period in genotype B and C patients, respectively. These results remained similar when follow‐up was extended to nearly 3 years. In conclusion, no significant differences in clinical characteristics and response to IFN‐ α between genotypes B and C were found, probably, because both types shared a common pre‐C/C encoding region." @default.
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• W1985427864 date "2007-01-11" @default.
• W1985427864 modified "2023-10-16" @default.
• W1985427864 title "No significant differences in histology and response to interferon treatment in hepatitis B carriers of genotypes C and recombinant B" @default.
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• W1985427864 doi "https://doi.org/10.1111/j.1365-2893.2006.00825.x" @default.
• W1985427864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17501763" @default.
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