Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985441668> ?p ?o ?g. }
- W1985441668 endingPage "664" @default.
- W1985441668 startingPage "660" @default.
- W1985441668 abstract "To investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n=1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n=482) and in a gestational diabetes study (n=1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation." @default.
- W1985441668 created "2016-06-24" @default.
- W1985441668 creator A5007674793 @default.
- W1985441668 creator A5008074124 @default.
- W1985441668 creator A5010886480 @default.
- W1985441668 creator A5025154088 @default.
- W1985441668 creator A5029552326 @default.
- W1985441668 creator A5039106969 @default.
- W1985441668 creator A5041807954 @default.
- W1985441668 creator A5043571184 @default.
- W1985441668 creator A5046334289 @default.
- W1985441668 creator A5050460445 @default.
- W1985441668 creator A5073241182 @default.
- W1985441668 creator A5075493235 @default.
- W1985441668 creator A5083444011 @default.
- W1985441668 creator A5086609611 @default.
- W1985441668 creator A5087520494 @default.
- W1985441668 date "2012-09-06" @default.
- W1985441668 modified "2023-10-16" @default.
- W1985441668 title "Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition" @default.
- W1985441668 cites W1964328841 @default.
- W1985441668 cites W1965636834 @default.
- W1985441668 cites W1968694304 @default.
- W1985441668 cites W1970780765 @default.
- W1985441668 cites W1971901884 @default.
- W1985441668 cites W1977875804 @default.
- W1985441668 cites W1987714056 @default.
- W1985441668 cites W1995268827 @default.
- W1985441668 cites W1996570221 @default.
- W1985441668 cites W2005550448 @default.
- W1985441668 cites W2006400809 @default.
- W1985441668 cites W2007078899 @default.
- W1985441668 cites W2018619500 @default.
- W1985441668 cites W2020588240 @default.
- W1985441668 cites W2021876362 @default.
- W1985441668 cites W2026599443 @default.
- W1985441668 cites W2042332011 @default.
- W1985441668 cites W2046360553 @default.
- W1985441668 cites W2058667120 @default.
- W1985441668 cites W2063230832 @default.
- W1985441668 cites W2075267662 @default.
- W1985441668 cites W2082384239 @default.
- W1985441668 cites W2083760442 @default.
- W1985441668 cites W2083924917 @default.
- W1985441668 cites W2099383053 @default.
- W1985441668 cites W2100377939 @default.
- W1985441668 cites W2104494570 @default.
- W1985441668 cites W2109619031 @default.
- W1985441668 cites W2111509153 @default.
- W1985441668 cites W2112392385 @default.
- W1985441668 cites W2113025136 @default.
- W1985441668 cites W2135184155 @default.
- W1985441668 cites W2136787741 @default.
- W1985441668 cites W2138438495 @default.
- W1985441668 cites W2140609764 @default.
- W1985441668 cites W2148072726 @default.
- W1985441668 cites W2161939149 @default.
- W1985441668 cites W2164654425 @default.
- W1985441668 cites W2328149637 @default.
- W1985441668 doi "https://doi.org/10.1038/jhg.2012.92" @default.
- W1985441668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22951595" @default.
- W1985441668 hasPublicationYear "2012" @default.
- W1985441668 type Work @default.
- W1985441668 sameAs 1985441668 @default.
- W1985441668 citedByCount "42" @default.
- W1985441668 countsByYear W19854416682013 @default.
- W1985441668 countsByYear W19854416682014 @default.
- W1985441668 countsByYear W19854416682015 @default.
- W1985441668 countsByYear W19854416682016 @default.
- W1985441668 countsByYear W19854416682017 @default.
- W1985441668 countsByYear W19854416682019 @default.
- W1985441668 countsByYear W19854416682020 @default.
- W1985441668 countsByYear W19854416682021 @default.
- W1985441668 countsByYear W19854416682022 @default.
- W1985441668 countsByYear W19854416682023 @default.
- W1985441668 crossrefType "journal-article" @default.
- W1985441668 hasAuthorship W1985441668A5007674793 @default.
- W1985441668 hasAuthorship W1985441668A5008074124 @default.
- W1985441668 hasAuthorship W1985441668A5010886480 @default.
- W1985441668 hasAuthorship W1985441668A5025154088 @default.
- W1985441668 hasAuthorship W1985441668A5029552326 @default.
- W1985441668 hasAuthorship W1985441668A5039106969 @default.
- W1985441668 hasAuthorship W1985441668A5041807954 @default.
- W1985441668 hasAuthorship W1985441668A5043571184 @default.
- W1985441668 hasAuthorship W1985441668A5046334289 @default.
- W1985441668 hasAuthorship W1985441668A5050460445 @default.
- W1985441668 hasAuthorship W1985441668A5073241182 @default.
- W1985441668 hasAuthorship W1985441668A5075493235 @default.
- W1985441668 hasAuthorship W1985441668A5083444011 @default.
- W1985441668 hasAuthorship W1985441668A5086609611 @default.
- W1985441668 hasAuthorship W1985441668A5087520494 @default.
- W1985441668 hasBestOaLocation W19854416681 @default.
- W1985441668 hasConcept C104317684 @default.
- W1985441668 hasConcept C106208931 @default.
- W1985441668 hasConcept C126322002 @default.
- W1985441668 hasConcept C134018914 @default.
- W1985441668 hasConcept C135763542 @default.
- W1985441668 hasConcept C137627325 @default.