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• W1985442760 abstract "Cell polarization occurs along a single axis that is generally determined by a spatial cue. Cells of the budding yeast Saccharomyces cerevisiae select a site for polarized growth in a specific pattern depending on cell type. Haploid a and α cells bud in the axial budding pattern, which depends on a transient marker and requires proteins Bud3, Bud4, Axl1 and Axl2. Here we report that Bud4 functions as a platform that mediates the ordered assembly of the axial landmark at the division site during M and early G1. While Bud4 associates with Bud3 in all cell types and in the absence of Axl1 or Axl2, Bud4 interacts with Axl1 and Axl2 mainly in haploid cells and only in the presence of all other components of the landmark. Bud4 can bind to GTP or GDP, and a GTP binding-defective Bud4 fails to interact with Axl1 in vitro. The same bud4 mutation leads to mis-localization of Axl1 and disrupts the axial budding pattern, indicating that GTP binding to Bud4 is important for its role in bud-site selection. We also show the cell-type-specific association of the axial landmark with Bud5, a GDP/GTP exchange factor for Rsr1. Despite their expression in all cell types, Bud4 and Axl2 associate with Bud5 specifically in haploid cells and in the presence of Axl1, whose expression is limited to a and α cells. Together, our findings suggest that Bud4 plays a critical role in the assembly of the axial landmark and its link to the Rsr1 GTPase module." @default.
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• W1985442760 date "2012-01-01" @default.
• W1985442760 modified "2023-09-30" @default.
• W1985442760 title "Bud4 mediates the cell-type-specific assembly of the axial landmark in budding yeast" @default.
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• W1985442760 doi "https://doi.org/10.1242/jcs.103697" @default.
• W1985442760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3462081" @default.
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