Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985448376> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1985448376 endingPage "841" @default.
- W1985448376 startingPage "837" @default.
- W1985448376 abstract "Abstract The effects of pancuronium bromide infusion on the uptake and release of [14C] noradrenaline (14C-NA) by the isolated, perfused rat heart and on the chronotropic and inotropic activity of the isolated heart were evaluated. Hearts were removed from animals under light ether anaesthesia, transferred to a modified Langendorff perfusing apparatus and perfused with Krebs-Ringer bicarbonate solution at a rate of 5 ml min−1. The effect of pancuronium on the uptake of noradrenaline was determined by perfusing hearts for 5 min with perfusate containing various concentrations of pancuronium and 200 ng ml−1 of 14C-NA. After 5 min pancuronium-treated hearts contained less 14C-NA. The degree of reduced uptake increased with increasing concentrations of pancuronium. In addition, the combination of pancuronium perfusion and electrical stimulation (15 mA for 10 ms at 4 Hz) blocked the 50 min uptake of 14C-NA by the heart to a greater degree than either factor separately. The release of noradrenaline was determined after perfusing hearts with 14C-NA followed by perfusion with solution containing pancuronium but no 14C-NA for 1 h. Pancuronium infusion did not significantly alter the release of 14C-NA from the heart after 1 h of perfusion. The infusion of pancuronium caused a reduction in both the rate and strength of myocardial contraction of the isolated heart which was reversed by perfusion with perfusate free of pancuronium. Following perfusion with pancurnium the rate and strength of contraction of the heart was seen to “rebound” above pre-pancuronium values for a short period. The rebound of myocardial rate and contraction may have been due to the presence of myocardial noradrenaline previously blocked from reuptake by pancuronium since hearts removed from reserpinized animals did not demonstrate “rebound.”" @default.
- W1985448376 created "2016-06-24" @default.
- W1985448376 creator A5027721487 @default.
- W1985448376 creator A5044063648 @default.
- W1985448376 creator A5046856663 @default.
- W1985448376 creator A5055683077 @default.
- W1985448376 date "1975-11-01" @default.
- W1985448376 modified "2023-10-17" @default.
- W1985448376 title "The effect of pancuronium on myocardial contraction and catecholamine metabolism" @default.
- W1985448376 cites W175650625 @default.
- W1985448376 cites W1965671684 @default.
- W1985448376 cites W1995697277 @default.
- W1985448376 cites W2009156812 @default.
- W1985448376 cites W2021015648 @default.
- W1985448376 cites W2044197011 @default.
- W1985448376 cites W2070081788 @default.
- W1985448376 cites W2086427568 @default.
- W1985448376 cites W2103060565 @default.
- W1985448376 cites W4302052541 @default.
- W1985448376 cites W2315540758 @default.
- W1985448376 doi "https://doi.org/10.1111/j.2042-7158.1975.tb10226.x" @default.
- W1985448376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1492" @default.
- W1985448376 hasPublicationYear "1975" @default.
- W1985448376 type Work @default.
- W1985448376 sameAs 1985448376 @default.
- W1985448376 citedByCount "61" @default.
- W1985448376 countsByYear W19854483762015 @default.
- W1985448376 crossrefType "journal-article" @default.
- W1985448376 hasAuthorship W1985448376A5027721487 @default.
- W1985448376 hasAuthorship W1985448376A5044063648 @default.
- W1985448376 hasAuthorship W1985448376A5046856663 @default.
- W1985448376 hasAuthorship W1985448376A5055683077 @default.
- W1985448376 hasConcept C126322002 @default.
- W1985448376 hasConcept C146957229 @default.
- W1985448376 hasConcept C155710745 @default.
- W1985448376 hasConcept C158328960 @default.
- W1985448376 hasConcept C163415756 @default.
- W1985448376 hasConcept C185592680 @default.
- W1985448376 hasConcept C2777177457 @default.
- W1985448376 hasConcept C2777953023 @default.
- W1985448376 hasConcept C2781112554 @default.
- W1985448376 hasConcept C42219234 @default.
- W1985448376 hasConcept C71924100 @default.
- W1985448376 hasConcept C84393581 @default.
- W1985448376 hasConceptScore W1985448376C126322002 @default.
- W1985448376 hasConceptScore W1985448376C146957229 @default.
- W1985448376 hasConceptScore W1985448376C155710745 @default.
- W1985448376 hasConceptScore W1985448376C158328960 @default.
- W1985448376 hasConceptScore W1985448376C163415756 @default.
- W1985448376 hasConceptScore W1985448376C185592680 @default.
- W1985448376 hasConceptScore W1985448376C2777177457 @default.
- W1985448376 hasConceptScore W1985448376C2777953023 @default.
- W1985448376 hasConceptScore W1985448376C2781112554 @default.
- W1985448376 hasConceptScore W1985448376C42219234 @default.
- W1985448376 hasConceptScore W1985448376C71924100 @default.
- W1985448376 hasConceptScore W1985448376C84393581 @default.
- W1985448376 hasIssue "11" @default.
- W1985448376 hasLocation W19854483761 @default.
- W1985448376 hasLocation W19854483762 @default.
- W1985448376 hasOpenAccess W1985448376 @default.
- W1985448376 hasPrimaryLocation W19854483761 @default.
- W1985448376 hasRelatedWork W140326142 @default.
- W1985448376 hasRelatedWork W1971564964 @default.
- W1985448376 hasRelatedWork W2085011369 @default.
- W1985448376 hasRelatedWork W2092878964 @default.
- W1985448376 hasRelatedWork W2319938313 @default.
- W1985448376 hasRelatedWork W2348741148 @default.
- W1985448376 hasRelatedWork W2413198329 @default.
- W1985448376 hasRelatedWork W2950547776 @default.
- W1985448376 hasRelatedWork W2950799831 @default.
- W1985448376 hasRelatedWork W576616620 @default.
- W1985448376 hasVolume "27" @default.
- W1985448376 isParatext "false" @default.
- W1985448376 isRetracted "false" @default.
- W1985448376 magId "1985448376" @default.
- W1985448376 workType "article" @default.