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• W1985452888 abstract "Complementary deoxyribonucleic acid microarray data from 36 mice subjected for 1, 2, or 4 weeks of their early life to normal atmospheric conditions (normoxia) or chronic intermittent (CIH) or constant (CCH) hypoxia were analyzed to extract organizational principles of the developing heart transcriptome and determine the integrated response to oxygen deprivation. Although both CCH and CIH regulated numerous genes involved in a wide diversity of processes, the changes in maturational profile, expression stability, and coordination were vastly different between the two treatments, indicating the activation of distinct regulatory mechanisms of gene transcription. The analysis focused on the main regulators of translation and response to stress because of their role in the cardiac hypertrophy and cell survival in hypoxia. On average, the expression of each heart gene was tied to the expression of about 20% of other genes in normoxia but to only 8% in CCH and 9% in CIH, indicating a strong decoupling effect of hypoxia. In contrast to the general tendency, the interlinkages among components of the translational machinery and response to stress increased significantly in CIH and much more in CCH, suggesting a coordinated response to the hypoxic stress. Moreover, the transcriptomic networks were profoundly and differently remodeled by CCH and CIH." @default.
• W1985452888 created "2016-06-24" @default.
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• W1985452888 creator A5011180447 @default.
• W1985452888 creator A5051420597 @default.
• W1985452888 creator A5083455648 @default.
• W1985452888 date "2008-05-01" @default.
• W1985452888 modified "2023-10-03" @default.
• W1985452888 title "Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival" @default.
• W1985452888 cites W1530921593 @default.
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• W1985452888 cites W1965391324 @default.
• W1985452888 cites W1968733054 @default.
• W1985452888 cites W1970118869 @default.
• W1985452888 cites W1978728980 @default.
• W1985452888 cites W1980435646 @default.
• W1985452888 cites W1991468158 @default.
• W1985452888 cites W1991625441 @default.
• W1985452888 cites W2003540622 @default.
• W1985452888 cites W2009328278 @default.
• W1985452888 cites W2011337895 @default.
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• W1985452888 cites W2012298102 @default.
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• W1985452888 cites W2021155493 @default.
• W1985452888 cites W2023252793 @default.
• W1985452888 cites W2024229944 @default.
• W1985452888 cites W2026736660 @default.
• W1985452888 cites W2033774852 @default.
• W1985452888 cites W2034978492 @default.
• W1985452888 cites W2037629730 @default.
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• W1985452888 cites W2086939601 @default.
• W1985452888 cites W2086964102 @default.
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• W1985452888 doi "https://doi.org/10.1007/s10142-008-0082-y" @default.
• W1985452888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2856931" @default.
• W1985452888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18446526" @default.
• W1985452888 hasPublicationYear "2008" @default.
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