FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985454759> ?p ?o ?g. }

• W1985454759 endingPage "77" @default.
• W1985454759 startingPage "69" @default.
• W1985454759 abstract "We examined the role of selenium (Se) in the mechanism of oxidative stress caused by endotoxin by feeding rats deficient a diet in this element. In rats fed the Se-deficient diet (concentration of Se, less than 0.027 μg g−1) for 10 weeks, Se level and glutathione peroxidase (GSH-Px) activity in the liver were about 47 and 43% lower, respectively, than those in rats fed a Se-adequate diet (Se, 0.2 μg g−1). Rat fed the Se-deficient diet and given endotoxin (6 mg kg−1, i.p.) showed a mortality rates of about 43% at 18 h. Nevertheless, no lethality was observed with endotoxin (4 mg kg−1, i.p.) challenge. Levels of serum lactate dehydrogenase and acid phosphatase leakage were significantly higher in Se-deficient rats than those in Se-adequate diet 18 h after endotoxin (4 mg kg−1, i.p.) challenge. Superoxide anion generation and lipid peroxide formation in the liver of Se-deficient rat were markedly increased 18 h after endotoxin (4 mg kg−1, i.p.) injection compared with those in the endotoxin/Se-adequate diet group, whereas non-protein sulfhydryl level in the liver after administration of endotoxin to Se-deficient rats was lower than that in Se-adequate rats treated with endotoxin. We investigated whether Se can suppress nitric oxide (NO) generation and cytotoxicity in endotoxin-treated J774A.1 cells. Treatment with Se (10−6 M) markedly inhibited endotoxin (0.1 μg ml−1)-induced NO production in J774A.1 cells. Se induced an increased activity of GSH-Px in cells after 24 h of incubation, suggesting that the preventive effect of Se on NO production in endotoxemia is due to the induction of Se–GSH-Px activity. However, Se did not affect endotoxin-induced cytotoxicity in J774A.1 cells. These findings suggested that the oxidative stress caused by endotoxin may be due, at least in part, to changes in Se regulation during endotoxemia." @default.
• W1985454759 created "2016-06-24" @default.
• W1985454759 creator A5044573833 @default.
• W1985454759 creator A5050562935 @default.
• W1985454759 creator A5054593903 @default.
• W1985454759 creator A5064831753 @default.
• W1985454759 creator A5067170473 @default.
• W1985454759 creator A5076918333 @default.
• W1985454759 date "2000-12-01" @default.
• W1985454759 modified "2023-09-26" @default.
• W1985454759 title "Roles of selenium in endotoxin-induced lipid peroxidation in the rats liver and in nitric oxide production in J774A.1 cells" @default.
• W1985454759 cites W165889239 @default.
• W1985454759 cites W1775749144 @default.
• W1985454759 cites W1821918060 @default.
• W1985454759 cites W1967315269 @default.
• W1985454759 cites W1972438028 @default.
• W1985454759 cites W1977651412 @default.
• W1985454759 cites W1978261657 @default.
• W1985454759 cites W1983310681 @default.
• W1985454759 cites W1990802251 @default.
• W1985454759 cites W2016427798 @default.
• W1985454759 cites W2016584191 @default.
• W1985454759 cites W2053466100 @default.
• W1985454759 cites W2055090334 @default.
• W1985454759 cites W2075166913 @default.
• W1985454759 cites W2078698544 @default.
• W1985454759 cites W2097744068 @default.
• W1985454759 cites W2122515902 @default.
• W1985454759 cites W2134596659 @default.
• W1985454759 cites W2162514672 @default.
• W1985454759 cites W2168793993 @default.
• W1985454759 cites W2274550965 @default.
• W1985454759 cites W2278211428 @default.
• W1985454759 cites W4210999932 @default.
• W1985454759 cites W786125826 @default.
• W1985454759 cites W363792520 @default.
• W1985454759 doi "https://doi.org/10.1016/s0378-4274(00)00263-0" @default.
• W1985454759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11137311" @default.
• W1985454759 hasPublicationYear "2000" @default.
• W1985454759 type Work @default.
• W1985454759 sameAs 1985454759 @default.
• W1985454759 citedByCount "25" @default.
• W1985454759 countsByYear W19854547592013 @default.
• W1985454759 countsByYear W19854547592014 @default.
• W1985454759 countsByYear W19854547592017 @default.
• W1985454759 crossrefType "journal-article" @default.
• W1985454759 hasAuthorship W1985454759A5044573833 @default.
• W1985454759 hasAuthorship W1985454759A5050562935 @default.
• W1985454759 hasAuthorship W1985454759A5054593903 @default.
• W1985454759 hasAuthorship W1985454759A5064831753 @default.
• W1985454759 hasAuthorship W1985454759A5067170473 @default.
• W1985454759 hasAuthorship W1985454759A5076918333 @default.
• W1985454759 hasConcept C126322002 @default.
• W1985454759 hasConcept C134018914 @default.
• W1985454759 hasConcept C178790620 @default.
• W1985454759 hasConcept C181199279 @default.
• W1985454759 hasConcept C185592680 @default.
• W1985454759 hasConcept C2776151105 @default.
• W1985454759 hasConcept C2777318727 @default.
• W1985454759 hasConcept C2778760513 @default.
• W1985454759 hasConcept C2780795997 @default.
• W1985454759 hasConcept C2780829032 @default.
• W1985454759 hasConcept C2993790521 @default.
• W1985454759 hasConcept C519581460 @default.
• W1985454759 hasConcept C538909803 @default.
• W1985454759 hasConcept C553756173 @default.
• W1985454759 hasConcept C55493867 @default.
• W1985454759 hasConcept C71924100 @default.
• W1985454759 hasConcept C86803240 @default.
• W1985454759 hasConceptScore W1985454759C126322002 @default.
• W1985454759 hasConceptScore W1985454759C134018914 @default.
• W1985454759 hasConceptScore W1985454759C178790620 @default.
• W1985454759 hasConceptScore W1985454759C181199279 @default.
• W1985454759 hasConceptScore W1985454759C185592680 @default.
• W1985454759 hasConceptScore W1985454759C2776151105 @default.
• W1985454759 hasConceptScore W1985454759C2777318727 @default.
• W1985454759 hasConceptScore W1985454759C2778760513 @default.
• W1985454759 hasConceptScore W1985454759C2780795997 @default.
• W1985454759 hasConceptScore W1985454759C2780829032 @default.
• W1985454759 hasConceptScore W1985454759C2993790521 @default.
• W1985454759 hasConceptScore W1985454759C519581460 @default.
• W1985454759 hasConceptScore W1985454759C538909803 @default.
• W1985454759 hasConceptScore W1985454759C553756173 @default.
• W1985454759 hasConceptScore W1985454759C55493867 @default.
• W1985454759 hasConceptScore W1985454759C71924100 @default.
• W1985454759 hasConceptScore W1985454759C86803240 @default.
• W1985454759 hasIssue "1-2" @default.
• W1985454759 hasLocation W19854547591 @default.
• W1985454759 hasLocation W19854547592 @default.
• W1985454759 hasOpenAccess W1985454759 @default.
• W1985454759 hasPrimaryLocation W19854547591 @default.
• W1985454759 hasRelatedWork W1992121509 @default.
• W1985454759 hasRelatedWork W2015274231 @default.
• W1985454759 hasRelatedWork W2034242699 @default.
• W1985454759 hasRelatedWork W2070656560 @default.
• W1985454759 hasRelatedWork W2172286882 @default.
• W1985454759 hasRelatedWork W2332315579 @default.
• W1985454759 hasRelatedWork W2349628382 @default.

• next