FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985457066> ?p ?o ?g. }

• W1985457066 endingPage "175" @default.
• W1985457066 startingPage "168" @default.
• W1985457066 abstract "Subependymomas are usually treated with surgical resection; however, no standard, defined alternative medical therapy is recommended for patients who are not surgical candidates, owing to a paucity of molecular, immunological, and genetic characterization. To address this, an ex vivo functional analysis of the immune microenvironment in subependymoma was conducted, a subependymoma cytokine/chemokine microarray was constructed for the evaluation of operational immune and molecular pathways, and a subependymoma cell line was derived and used to test a variety of cytotoxic agents that target operational pathways identified in subependymoma. We found that immune effectors are detectable within the microenvironment of subependymoma; however, marked immune suppression is not observed. The subependymoma tissue microarrays demonstrated tumor expression of p53, MDM2, HIF-1α, topoisomerase II-β, p-STAT3, and nucleolin, but not EGFRvIII, EphA2, IL-13RA2, CMV, CTLA-4, FoxP3, PD-1, PD-L1, EGFR, PDGF-α, PDGF-β, PDGFR-α, PDGFR-β, PTEN, IGFBP2, PI3K, MDM4, IDH1, mTOR, or Jak2. A topoisomerase inhibitor (WP744, IC50 = 0.83 μM) and a p-STAT3/HIF-1α inhibitor (WP1066, IC50 = 3.15 μM) demonstrated a growth inhibition of the subependymoma cell proliferation. Cumulatively, these data suggest that those agents that interfere with oncogenes operational in subependymoma may have clinical impact." @default.
• W1985457066 created "2016-06-24" @default.
• W1985457066 creator A5012403937 @default.
• W1985457066 creator A5022249471 @default.
• W1985457066 creator A5026767533 @default.
• W1985457066 creator A5038172006 @default.
• W1985457066 creator A5062959791 @default.
• W1985457066 creator A5062995405 @default.
• W1985457066 creator A5064593201 @default.
• W1985457066 creator A5066544434 @default.
• W1985457066 creator A5079081497 @default.
• W1985457066 creator A5086792863 @default.
• W1985457066 creator A5091806633 @default.
• W1985457066 date "2014-12-01" @default.
• W1985457066 modified "2023-09-23" @default.
• W1985457066 title "Therapeutic targets in subependymoma" @default.
• W1985457066 cites W1965462445 @default.
• W1985457066 cites W1965963990 @default.
• W1985457066 cites W2010956784 @default.
• W1985457066 cites W2018233112 @default.
• W1985457066 cites W2021750163 @default.
• W1985457066 cites W2027382240 @default.
• W1985457066 cites W2028753187 @default.
• W1985457066 cites W2039483976 @default.
• W1985457066 cites W2047394764 @default.
• W1985457066 cites W2053588414 @default.
• W1985457066 cites W2053815296 @default.
• W1985457066 cites W2059328247 @default.
• W1985457066 cites W2068958639 @default.
• W1985457066 cites W2072954179 @default.
• W1985457066 cites W2097049582 @default.
• W1985457066 cites W2097995306 @default.
• W1985457066 cites W2100062742 @default.
• W1985457066 cites W2106466891 @default.
• W1985457066 cites W2106537986 @default.
• W1985457066 cites W2110265246 @default.
• W1985457066 cites W2120026864 @default.
• W1985457066 cites W2124199305 @default.
• W1985457066 cites W2128066516 @default.
• W1985457066 cites W2128879464 @default.
• W1985457066 cites W2136800651 @default.
• W1985457066 cites W2137605317 @default.
• W1985457066 cites W2137930630 @default.
• W1985457066 cites W2138419309 @default.
• W1985457066 cites W2147596506 @default.
• W1985457066 cites W2148131374 @default.
• W1985457066 cites W2160834915 @default.
• W1985457066 cites W2119190478 @default.
• W1985457066 doi "https://doi.org/10.1016/j.jneuroim.2014.10.008" @default.
• W1985457066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25465288" @default.
• W1985457066 hasPublicationYear "2014" @default.
• W1985457066 type Work @default.
• W1985457066 sameAs 1985457066 @default.
• W1985457066 citedByCount "17" @default.
• W1985457066 countsByYear W19854570662015 @default.
• W1985457066 countsByYear W19854570662016 @default.
• W1985457066 countsByYear W19854570662017 @default.
• W1985457066 countsByYear W19854570662018 @default.
• W1985457066 countsByYear W19854570662019 @default.
• W1985457066 countsByYear W19854570662020 @default.
• W1985457066 countsByYear W19854570662021 @default.
• W1985457066 countsByYear W19854570662022 @default.
• W1985457066 crossrefType "journal-article" @default.
• W1985457066 hasAuthorship W1985457066A5012403937 @default.
• W1985457066 hasAuthorship W1985457066A5022249471 @default.
• W1985457066 hasAuthorship W1985457066A5026767533 @default.
• W1985457066 hasAuthorship W1985457066A5038172006 @default.
• W1985457066 hasAuthorship W1985457066A5062959791 @default.
• W1985457066 hasAuthorship W1985457066A5062995405 @default.
• W1985457066 hasAuthorship W1985457066A5064593201 @default.
• W1985457066 hasAuthorship W1985457066A5066544434 @default.
• W1985457066 hasAuthorship W1985457066A5079081497 @default.
• W1985457066 hasAuthorship W1985457066A5086792863 @default.
• W1985457066 hasAuthorship W1985457066A5091806633 @default.
• W1985457066 hasConcept C2776107976 @default.
• W1985457066 hasConcept C3020616263 @default.
• W1985457066 hasConcept C502942594 @default.
• W1985457066 hasConcept C86803240 @default.
• W1985457066 hasConceptScore W1985457066C2776107976 @default.
• W1985457066 hasConceptScore W1985457066C3020616263 @default.
• W1985457066 hasConceptScore W1985457066C502942594 @default.
• W1985457066 hasConceptScore W1985457066C86803240 @default.
• W1985457066 hasIssue "1-2" @default.
• W1985457066 hasLocation W19854570661 @default.
• W1985457066 hasLocation W19854570662 @default.
• W1985457066 hasOpenAccess W1985457066 @default.
• W1985457066 hasPrimaryLocation W19854570661 @default.
• W1985457066 hasRelatedWork W2550267433 @default.
• W1985457066 hasRelatedWork W2943638659 @default.
• W1985457066 hasRelatedWork W4224234798 @default.
• W1985457066 hasRelatedWork W4226093359 @default.
• W1985457066 hasRelatedWork W4246325350 @default.
• W1985457066 hasRelatedWork W4282924010 @default.
• W1985457066 hasRelatedWork W4319868994 @default.
• W1985457066 hasRelatedWork W4378212392 @default.
• W1985457066 hasRelatedWork W4381377675 @default.
• W1985457066 hasRelatedWork W3111500367 @default.
• W1985457066 hasVolume "277" @default.

• next