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- W1985458872 abstract "The aim of this study was to assess the toxicological risks arising from the coexistence of polyethylene glycol coated single-walled carbon nanotubes (SWCNTs-PEG) and a known environmental contaminant: 4-nonylphenol (NP). To this end, in vitro toxicity assays involving the exposure of 3T3-L1 cells (mouse embryonic fibroblasts) to SWCNTs-PEG alone or in combination with NP for 24 or 48 h were performed. Experimental treatments were conducted in both presence (10%) and absence of serum in order to evaluate its influence on the toxicity of SWCNTs-PEG. Although the results provided no unambiguous evidences of synergistic toxicity between SWCNTs-PEG and NP, some specific treatments with mixtures (SWCNTs-PEG + NP) resulted in an unexpected combined toxicity in relation to the individual treatments. Only in those cases the interaction between SWCNTs-PEG and NP could have a synergistic effect on the resulting toxicity. The addition of 10% serum increased the stability of SWCNTs-PEG in the culture medium—possibly by steric repulsions—and reduced the toxicity of nanoparticles as a result. Overall, the serum had a “protective effect” on cells against all treatments: SWCNTs-PEG, NP or their mixtures (SWCNTs-PEG + NP). Raman spectroscopy allowed the intracellular distribution of SWCNTs-PEG to be elucidated." @default.
- W1985458872 created "2016-06-24" @default.
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- W1985458872 date "2014-06-01" @default.
- W1985458872 modified "2023-10-12" @default.
- W1985458872 title "Effects of the interaction of single-walled carbon nanotubes with 4-nonylphenol on their in vitro toxicity" @default.
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- W1985458872 doi "https://doi.org/10.1016/j.jhazmat.2014.04.055" @default.
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