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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985461195> ?p ?o ?g. }

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• W1985461195 abstract "We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14 activity in B16F1 melanoma cells. Our results suggest that a direct interaction occurs between lumican and MMP-14. Lumican behaves as a competitive inhibitor which leads to a complete blocking of the activity of MMP-14. It binds to the catalytic domain of MMP-14 with moderate affinity (K D ∼ 275 nM). Lumican may protect collagen against MMP-14 proteolysis, thus influencing cell–matrix interaction in tumor progression." @default.
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• W1985461195 date "2014-10-07" @default.
• W1985461195 modified "2023-10-17" @default.
• W1985461195 title "Lumican: A new inhibitor of matrix metalloproteinase-14 activity" @default.
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• W1985461195 doi "https://doi.org/10.1016/j.febslet.2014.09.040" @default.
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