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• W1985472208 endingPage "2469" @default.
• W1985472208 startingPage "2461" @default.
• W1985472208 abstract "Subjects with poorly controlled type 2 diabetes are both hyperglycemic and insulin resistant. To determine whether short term restoration of normoglycemia improves insulin action, hyperinsulinemic (approximately 300 pmol/L) euglycemic clamps were performed in diabetic subjects after either overnight infusion of saline or overnight infusion of insulin in amounts sufficient to maintain euglycemia throughout the night. Fasting glucose concentrations (5.2 +/- 0.2 vs. 11.9 +/- 1.4 mmol/L; P < 0.01) and rates of endogenous glucose production (13.0 +/- 1.1 vs. 18.6 +/- 1.6 mumol/kg.min; P < 0.05) were both lower after overnight insulin than overnight saline. Insulin-induced stimulation of glucose uptake (to 34.9 +/- 6.8 vs. 28.8 +/- 3.4 mumol/kg.min; P = 0.2) and inhibition of free fatty acids (to 0.13 +/- 0.03 vs. 0.12 +/- 0.04 mmol/L; P = 0.6) did not differ after overnight saline and overnight insulin. In contrast, endogenous glucose production during the final hour of the hyperinsulinemic clamps (i.e. when glucose concentrations were the same) remained higher (P = 0.05) after overnight saline than after overnight insulin (5.5 +/- 1.5 vs. 0.02 +/- 1.4 mumol/kg.min). Thus, acute restoration of euglycemia by means of an overnight insulin infusion improves hepatic (and perhaps renal) but not extrahepatic insulin action." @default.
• W1985472208 created "2016-06-24" @default.
• W1985472208 creator A5028414583 @default.
• W1985472208 creator A5034690530 @default.
• W1985472208 creator A5036276009 @default.
• W1985472208 creator A5073547744 @default.
• W1985472208 date "1998-07-01" @default.
• W1985472208 modified "2023-09-23" @default.
• W1985472208 title "Overnight Normalization of Glucose Concentrations Improves Hepatic But Not Extrahepatic Insulin Action in Subjects with Type 2 Diabetes Mellitus1" @default.
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• W1985472208 doi "https://doi.org/10.1210/jcem.83.7.4976" @default.
• W1985472208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9661629" @default.
• W1985472208 hasPublicationYear "1998" @default.
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