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• W1985478285 abstract "The present study aimed to analyze the gene and protein expression and the pattern of distribution of the vanilloid receptors TRPV1 and TRPV2 in the developing rat retina. During the early phases of development, TRPV1 was found mainly in the neuroblastic layer of the retina and in the pigmented epithelium. In the adult, TRPV1 was found in microglial cells, blood vessels, astrocytes and in neuronal structures, namely synaptic boutons of both retinal plexiform layers, as well as in cell bodies of the inner nuclear layer and the ganglion cell layer. The pattern of distribution of TRPV1 was mainly punctate, and there was higher TRPV1 labeling in the peripheral retina than in central regions. TRPV2 expression was quite distinct. Its expression was virtually undetectable by immunoblotting before P1, and that receptor was found by immunohistochemistry only by postnatal day 15 (P15). RNA and protein analysis showed that the adult levels are only reached by P60, which includes small processes in the retinal plexiform layers, and labeled cellular bodies in the inner nuclear layer and the ganglion cell layer. There was no overlapping between the signal observed for both receptors. In conclusion, our results showed that the patterns of distribution of TRPV1 and TRPV2 are different during the development of the rat retina, suggesting that they have specific roles in both visual processing and in providing specific cues to neural development." @default.
• W1985478285 created "2016-06-24" @default.
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• W1985478285 date "2009-07-18" @default.
• W1985478285 modified "2023-09-27" @default.
• W1985478285 title "Ontogenetic expression of the vanilloid receptors TRPV1 and TRPV2 in the rat retina" @default.
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• W1985478285 doi "https://doi.org/10.1016/j.ijdevneu.2009.07.003" @default.
• W1985478285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19619635" @default.
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