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• W1985479289 abstract "Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly and CAA is also a surrogate marker of small vessel diseases, such as microbleeds and subcortical ischemic infarctions. Diagnosis of CAA requires pathologic evidence of amyloid deposition in cerebral blood vessels and a probable CAA has traditionally been diagnosed by Boston's criteria based on clinical history and MRI findings of intracranial hemorrhages. However, multiple lobar microbleeds are frequently observed in the community dwelling elderly, particularly who have vascular risk factors. Moreover, sometimes it is tough to discriminate CAA from other multiple intracranial hemorrhages, which have different treatment modalities and prognosis. Therefore, we investigated clinical characteristics of probable CAA based on Boston's criteria and also investigated predictive factors associated with certain features of CAA. We retrospectively reviewed patients diagnosed as probable CAA based on the Boston's criteria who underwent MRI, including gradient echo (GRE) and fluid attenuated inversion recovery (FLAIR) images and clinical assessment from August 2006 to May 2013. All GRE images of each subject were reviewed by 1 rater to describe the location and numbers of intracranial hemorrhages. The white matter hyperintensity was rated based on rating scales proposed by Clinical Research Center for Dementia of South Korea (CREDOS). Statistical analyses were performed using SPSS version 21.0 and SAS 6.0. A total of 92 patients were included in this study. The mean age of onset was 68.6±9.9 years (M:F=61:31). Sixty-three patients (68%) had hypertension. The initial diagnoses included cognitive impairment (48 patients, 52%), lobar ICH (14 patients, 15.2%), and lacunar infarction (10 patients, 10.9%). Thirty-nine patients had deep microbleeds. Fifty-three patients (57%) showed posterior dominant distribution (parietal and occipital lobe) of hemorrhages. The median number of microbleeds was 15 [interquartile range (IQR): 7-41.33]. Patients with posterior dominant location were older (p =0.028) and complained of cognitive decline more often (p =0.034). This group had more microbleeds (p =0.006) and showed more severe white matter hyperintensities (p =0.008). They also tended to have lower recall score of MMSE than the other group. Patients with deep microbleeds showed more severe white matter hyperintensities (p =0.002). Twenty-four patients performed follow-up MR imaging. The mean interval time was 28.6±24.2 months. Large number of microbleeds at baseline was associated with increasing rate of new microbleeds at follow-up scan. We found the impact of location of intracranial hemorrhages on cognitive impairment and white matter hyperintensities in patients with CAA. The distribution and the number of microbleeds at baseline were factors associated with disease progression. These data indicate that early evaluation of the location and number of microbleeds can be helpful to assess clinical characteristics and prognosis in patients with probable CAA." @default.
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• W1985479289 date "2014-07-01" @default.
• W1985479289 modified "2023-09-27" @default.
• W1985479289 title "P3-229: CLINICAL CHARACTERISTICS AND MRI FINDINGS IN PATIENTS WITH CAA" @default.
• W1985479289 doi "https://doi.org/10.1016/j.jalz.2014.05.1320" @default.
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