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- W1985482184 abstract "Case Studies1 November 1966On the Origin of AmyloidStudy of an Amyloid Tumor in Multiple MyelomaJOSEPH GAFNI, M.D., HANS-JOACHIM MERKER, M.D., SHLOMO SHIBOLET, M.D., EZRA SOHAR, M.D., HARRY HELLER, M.D.JOSEPH GAFNI, M.D.Search for more papers by this author, HANS-JOACHIM MERKER, M.D.Search for more papers by this author, SHLOMO SHIBOLET, M.D.Search for more papers by this author, EZRA SOHAR, M.D.Search for more papers by this author, HARRY HELLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1031 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlmost since the discovery of amyloid there has been much speculation as to the mode and site of its formation. Its common association with protracted inflammatory diseases and multiple myeloma implicated the production, presumably by plasma cells, of a soluble abnormal protein that was carried by the circulation to the site of its precipitation by immune mechanisms in the connective tissue ground substance (1-4). The finding of plasma cell infiltrates in meticulously re-examined cases of primary amyloidosis added weight to this theory (5, 6). In recent years, however, the local deposition of such a distantly produced precursor has been denied...References1. JUERGENS R: Eine neue Reaktion auf Amyloidkoerper. Arch. Path. Anat. 65: 189, 1875. CrossrefGoogle Scholar2. APITZ K: Die Paraproteinosen (ueber die Stoerung des Eiweisstoffwechsels beim Plasmacytom). Arch. Path. Anat. 306: 1631, 1940. Google Scholar3. VASQUEZDIXON JJFJ: Immunohistochemical analysis of amyloid by the fluorescence technique. J. Exp. Med. 104: 727, 1956. CrossrefMedlineGoogle Scholar4. OSSERMAN EF: Amyloidosis: tissue proteinosis: gammaloidosis. Ann. Intern. Med. 55: 1033, 1961. LinkGoogle Scholar5. OSSERMAN EF: Plasma-cell myeloma. New Eng. J. Med. 261: 952, 1006, 1959. CrossrefMedlineGoogle Scholar6. KYLEBAYRD RRED: Primary systemic amyloidosis and myeloma. Discussion of relationship and review of 81 cases. Arch. Intern. Med. (Chicago) 107: 344, 1961. CrossrefMedlineGoogle Scholar7. CALKINSCOHENGITLIN EASD: Immunochemical determinations of gamma-globulin content of amyloid. Fed. Proc. 17: 1693, 1958. Google Scholar8. COHENPAUL ASWE: Relationship of gamma-globulin to the fibrils of secondary human amyloid. Nature (London) 197: 193, 1963. CrossrefMedlineGoogle Scholar9. BENDITTLAGUNOFFERIKSENISERI EPDNOA: Amyloid. Extraction and preliminary characterization of some proteins. Arch. Path. (Chicago) 74: 323, 1962. MedlineGoogle Scholar10. BENDITTLAGUNOFFERIKSENISERI EPDNOA: On the nature of amyloid (abstract). Program of the American Association of Pathology and Bacteriology, May 1962, p. 36. Google Scholar11. KENNEDY JS: Sulfur-35 in experimental amyloidosis. J. Path. Bact. 83: 165, 1962. CrossrefMedlineGoogle Scholar12. TEILUM G: PAS-positive reticuloendothelial cells producing amyloid. Amer. J. Path. 32: 945, 1956. MedlineGoogle Scholar13. TEILUM G: Pathogenesis of amyloidosis in the light of recent cystochemical investigations. Acta Rheum. Scand. 3: 164, 1957. CrossrefMedlineGoogle Scholar14. COHENGROSSSHIRAHAMA ASET: The light and electron microscopic autoradiographic demonstration of local amyloid formation in spleen explants. Amer. J. Path. 47: 1079, 1965. MedlineGoogle Scholar15. GAFNISOHARHELLER JEH: The inherited amyloidoses: their clinical and theoretical significance. Lancet 1: 71, 1964. CrossrefMedlineGoogle Scholar16. TALLAUFERZLOTNICK CAA: Experimental amyloidosis in mice: a patho-serological study. Brit. J. Exp. Path. 45: 323, 1964. MedlineGoogle Scholar17. 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Wm. Heinemann Medical Books Ltd. & Interscience Publishers, New York, 1960. Google Scholar23. HELLERMISSMAHLSOHARGAFNI HHPEJ: Amyloidosis: its differentiation into peri-reticulin and peri-collagen types. J. Path. Bact. 88: 15, 1964. CrossrefMedlineGoogle Scholar24. LETTERERCAESARVOGT ERA: Studien zur elektronenmikroskopischen und immuno-morphologischen Struktur des Amyloids. Deutsch. Med. Wschr. 85: 1909, 1960. CrossrefMedlineGoogle Scholar25. LETTERER E: Morphologische Folgen der Antigen-Antikoerper Reaktion. Verh. Deutsch. Ges. Path. 46: 83, 1962. MedlineGoogle Scholar26. CATHCARTCOHEN ESAS: The relation between isolated human amyloid fibrils and human gamma-globulin and its subunits. J. Immun. 96: 239, 1966. MedlineGoogle Scholar27. TEILUM G: Pathogenesis of amyloidosis: the two-phase cellular theory of local secretion. Acta Path. Microbiol. Scand. 61: 21, 1964. CrossrefMedlineGoogle Scholar28. COHENGROSSSHIRAHAMA ASET: The light and electron microscopic autoradiographic demonstration of local amyloid formation in spleen explants. Amer. J. Path. 47: 1079, 1965. MedlineGoogle Scholar29. SCHWARZ W: Fibrillogenese und Bildung der elastischen Fasern. Arch. Biol. (Liege) 75: 369, 1964. MedlineGoogle Scholar30. MOVATFERNANDO HZNV: The fine structure of connective tissue. I. The fibroblast. Exp. Molec. Path. 1: 509, 1962. CrossrefMedlineGoogle Scholar31. ROSSBENDITT REP: Wound healing and collagen formation. III. A quantitative radioautographic study of the utilization of proline-H3 in wounds from normal and scorbutic guinea pigs. J. Cell Biol. 15: 99, 1962. CrossrefMedlineGoogle Scholar32. GOLDBERGGREEN BH: An analysis of collagen secretion by established mouse fibroblast lines. J. Cell Biol. 22: 227, 1964. CrossrefMedlineGoogle Scholar33. WOHLFARTH-BOTTERMANN KE: Differentiation of the ground cytoplasm and their significance for the generation of the motive force of ameboid movement, in Primitive Motile Systems in Cell Biology, edited by ALLEN, R. D., KAMIYA, N. Academic Press, New York, 1964, pp. 79-109. CrossrefGoogle Scholar34. DICKLEITER GFL: Some factors in the development, localization and reabsorption of experimental amyloidosis in rabbits. Amer. J. Path. 17: 74, 1941. Google Scholar35. COHENCALKINS ASE: Electron microscopic observations on a fibrous component in amyloid of diverse origins. Nature (London) 183: 1202, 1959. CrossrefMedlineGoogle Scholar36. BOERERUINENSCHOLTEN HLJH: Electron microscopic studies on the fibrillar component of human splenic amyloid. J. Lab. Clin. Med. 66: 943, 1965. MedlineGoogle Scholar37. SHIRAHAMACOHEN TAS: Structure of amyloid fibrils after negative staining and high-resolution electron microscopy. Nature (London) 206: 737, 1965. CrossrefMedlineGoogle Scholar38. MERKERSHIBOLETSOHARGAFNIHELLER HJSEJH: Periodic cross-banding in amyloid filaments. Nature (London) 211: 1401, 1966. CrossrefMedlineGoogle Scholar39. HODGE AJ: Principles of ordering in fibrous systems, in Proceedings of the 4th International Congress of Electron Microscopy (Berlin, 1958). Springer, 1960, pp. 119-139. Google Scholar40. GROSS J: The behavior of collagen units as a model in morphogenesis. J. Biophys. Biochem. Cytol. 2 (suppl.): 261, 1956. CrossrefMedlineGoogle Scholar41. GAFNISOHARKARIVSHERFPRASSHELLERMANIMISSMAHLFRENSDORFFSHIBOLETBLUM JEILMHAHPASA: Milestones in the concept of familial Mediterranean fever. Proc. Tel Hashomer Hosp. 3: 13, 1964. Google Scholar42. SOHAR E: The genetic amyloidoses with special emphasis on familial Mediterranean fever. Henry Ford Hosp. Med. Bull. 12: 343, 1964. Google Scholar43. HASHIMOTO K: Personal communication, 1966. Google Scholar44. WOLFF J: Elektronenmikroskopische Untersuchungen ueber die Altersveraenderungen am Interstitiellen Bindegewebe des menschlichen Herzens. Z. Rheumaforsch 20: 175, 1961. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tel-Aviv,From the Departments of Medicine and Clinical Investigation, Tel-Aviv University Medical School and Tel-Hashomer Hospital, Tel-Aviv, Israel.This study was supported in part by research grant AM-09272, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Joseph Gafni, M.D., Tel-Hashomer Hospital, Tel-Aviv, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBinding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytesA Brief Review of the Ultrastructure of AmyloidPATHOLOGICAL STUDY ON AMYLOIDOSISHistochemical investigation of acid mucopolysaccharides in amyloid, colloid and hyalineTHE FINE STRUCTURE OF GLOMERULAR EPITHELIAL CELLS IN EXPERIMENTAL RENAL AMYLOIDOSISElektronenmikroskopische Befunde bei der sog. membranoproliferativen GlomerulonephritisElektronenmikroskopische Untersuchungen über die Amyloidose der Atrioventrikularklappen des HundesParaproteinämische HämoblastosenAmyloidosis and multiple myelomaFAMILIAL LICHEN AMYLOIDOSIS.Amyloidose der Herzklappen beim HundZur Pathogenese der senilen AmyloidoseLICHEN AMYLOIDOSIS.Diffuse alveolarseptale LungenamyloidoseAblagerungsdermatosen; Amyloidablagerungen in der HautAmyloid-bearing tumors of micePrimary amyloidosisPerikollagene Amyloidablagerungen in Haut und inneren Organen bei SklerodermiePrimary AmyloidosisWERNER F. BARTH, M.D., GEORGE G. GLENNER, M.D., THOMAS A. WALDMANN, M.D., ROBERT F. ZELIS, M.D.Primary amyloidosis with “monoclonal” immunoglobulin A proteinemiaDys- und Paraproteinämien bei AmyloidbefallAmyloidosis and the gutAmyloidosen bei chronisch-rheumatischen ErkrankungenColloid Milium: A Histochemical Study*Familial Mediterranean feverElectron-microscope observations on peri-reticulin and peri-collagen amyloidosis in rectal biopsiesElectron Microscope Observations of the Fine Structure of Microsporum Gypseum**From the Department of Zoology, Louisiana State University, Baton Rouge, Louisiana. 1 November 1966Volume 65, Issue 5Page: 1031-1044KeywordsAmyloidosisConnective tissue diseasesElectron microscopyHospital medicineImmunoprecipitationMultiple myelomaPlasma cellsPlasma proteinsResearch grantsSurgeons Issue Published: 1 November 1966 PDF downloadLoading ..." @default.
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