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- W1985482837 abstract "Castration-induced hypersecretion of pituitary LH was associated with a marked reduction in the medial basal hypothalamic (MBH) LHRH contents. Testosterone (T) therapy promptly reduced LH to intact serum levels within 24 h, while the MBH LHRH levels were restored only after 7 days. Withdrawal of T replacement caused hypersecretion of LH within 8 h, although the first significant decrease in the MBH LHRH contents occurred between days 4–7. The two metabolites of T, 5α-dihydrotestosterone (DHT) and 17β-estradiol (E2), were as effective as T in raising the MBH LHRH content; however, their effects on serum LH were variable. The antiandrogen flutamide, but not the antiestrogen nafoxidine hydrochloride, blocked the stimulatory effects of T and DHT on MBH LHRH levels. Nafoxidine treatment was also ineffective in reversing this central effect of E2. None of these treatments significantly altered LHRH content in the preoptic area (POA). In view of the wide distribution of LHRH-containing neurons in the septal POA ..." @default.
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- W1985482837 date "1980-01-01" @default.
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- W1985482837 title "Modulation of Hypothalamic Luteinizing Hormone-Releasing Hormone Levels by Intracranial and Subcutaneous Implants of Gonadal Steroids in Castrated Rats: Effects of Androgen and Estrogen Antagonists*" @default.
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- W1985482837 doi "https://doi.org/10.1210/endo-106-1-390" @default.
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