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- W1985492048 abstract "<i>Bub1</i> plays an important role at the spindle assembly checkpoint to prevent cell cycle progression following spindle damage. We examined the expression of human <i>Bub1</i> mRNA in 20 gastric carcinoma tissues and corresponding nonneoplastic mucosas by reverse transcriptase-polymerase chain reaction and analyzed the relation with proliferative activity monitored by the expression of proliferating cell nuclear antigen (PCNA) on Western blotting as well as Ki-67 labeling index by immunohistochemistry. Increased expression of <i>Bub1</i> mRNA was detected in 8 (40%) of the gastric carcinomas in comparison with their nonneoplastic counterparts, while 4 (20%) expressed <i>Bub1</i> at lower levels. The expression of <i>Bub1</i> mRNA was confirmed by in situ hybridization. The expression levels of <i>Bub1</i> mRNA were well correlated with the levels of PCNA protein in 16 (80%) gastric carcinoma cases. The examination of Ki-67 labeling indices proved the close correlation between the expression levels of <i>Bub1</i> and proliferating activity. These findings suggest that mRNA expression of human <i>Bub1</i> gene is closely associated with the tumor-proliferating activity. Since genetic alterations of human <i>Bub1</i> rarely occur in gastrointestinal cancers, the functional machinery of <i>Bub1</i> to prevent cell cycle progression into anaphase might be well preserved in gastric carcinomas even with high proliferative activity." @default.
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- W1985492048 date "2001-01-01" @default.
- W1985492048 modified "2023-10-15" @default.
- W1985492048 title "Expression of <i>Bub1</i> Gene Correlates with Tumor Proliferating Activity in Human Gastric Carcinomas" @default.
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- W1985492048 doi "https://doi.org/10.1159/000048754" @default.
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