Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985493485> ?p ?o ?g. }
- W1985493485 endingPage "313" @default.
- W1985493485 startingPage "298" @default.
- W1985493485 abstract "We have shown that cultured mouse neural crest (NC) cells exhibit transient increases in intracellular calcium. Up to 50% of the cultured NC-derived cells exhibited calcium transients during the period of neuronal differentiation. As neurogenic activity declined, so did the percentage of active NC-derived cells and their calcium spiking frequency. The decrease in calcium transient activity correlated with a decreased sensitivity to thimerosal, which sensitizes inositol 1,4,5-triphosphate receptors. Thimerosal increased the frequency of oscillations in active NC-derived cells and induced them in a subpopulation of quiescent cells. As neurogenesis ended, NC-derived cells became nonresponsive to thimerosal. Using the expression of time-dependent neuronal traits, we determined that neurons exhibited spontaneous calcium transients as early as a neuronal phenotype could be detected and continued through the acquisition of caffeine sensitivity, soon after which calcium transient activity stopped. A subpopulation of nonneuronal NC-derived cells exhibited calcium transient activity within the same time frame as neurogenesis in culture. Exposing NC-derived cells to 20 mM Mg(2+) blocked calcium transient activity and reduced neuronal number without affecting the survival of differentiated neurons. Using lineage-tracing analysis, we found that 50% of active NC-derived cells gave rise to clones containing neurons, while inactive cells did not. We hypothesize that calcium transient activity establishes a neuronal competence for undifferentiated NC cells." @default.
- W1985493485 created "2016-06-24" @default.
- W1985493485 creator A5041517232 @default.
- W1985493485 creator A5063712240 @default.
- W1985493485 date "1999-11-01" @default.
- W1985493485 modified "2023-09-23" @default.
- W1985493485 title "Spontaneous Calcium Transients Are Required for Neuronal Differentiation of Murine Neural Crest" @default.
- W1985493485 cites W1491900501 @default.
- W1985493485 cites W1492110909 @default.
- W1985493485 cites W1508787463 @default.
- W1985493485 cites W1517921781 @default.
- W1985493485 cites W1518265004 @default.
- W1985493485 cites W1570910223 @default.
- W1985493485 cites W1595587758 @default.
- W1985493485 cites W1650401181 @default.
- W1985493485 cites W173252389 @default.
- W1985493485 cites W1888933287 @default.
- W1985493485 cites W1920995666 @default.
- W1985493485 cites W1968177638 @default.
- W1985493485 cites W1970328692 @default.
- W1985493485 cites W1974113993 @default.
- W1985493485 cites W1975312645 @default.
- W1985493485 cites W1976498439 @default.
- W1985493485 cites W1980714951 @default.
- W1985493485 cites W1981543536 @default.
- W1985493485 cites W1987402927 @default.
- W1985493485 cites W1988677415 @default.
- W1985493485 cites W1988876772 @default.
- W1985493485 cites W1992529363 @default.
- W1985493485 cites W1992626984 @default.
- W1985493485 cites W1994109113 @default.
- W1985493485 cites W1997227155 @default.
- W1985493485 cites W2010613687 @default.
- W1985493485 cites W2011121871 @default.
- W1985493485 cites W2011799194 @default.
- W1985493485 cites W2022209059 @default.
- W1985493485 cites W2022729995 @default.
- W1985493485 cites W2022804978 @default.
- W1985493485 cites W2022990574 @default.
- W1985493485 cites W2027030154 @default.
- W1985493485 cites W2027416474 @default.
- W1985493485 cites W2028067698 @default.
- W1985493485 cites W2030014404 @default.
- W1985493485 cites W2036930489 @default.
- W1985493485 cites W2040516204 @default.
- W1985493485 cites W2047364183 @default.
- W1985493485 cites W2049367666 @default.
- W1985493485 cites W2051493425 @default.
- W1985493485 cites W2056429229 @default.
- W1985493485 cites W2057931636 @default.
- W1985493485 cites W2065217821 @default.
- W1985493485 cites W2066014797 @default.
- W1985493485 cites W2070694172 @default.
- W1985493485 cites W2071140879 @default.
- W1985493485 cites W2078147751 @default.
- W1985493485 cites W2081454368 @default.
- W1985493485 cites W2085628194 @default.
- W1985493485 cites W2092333455 @default.
- W1985493485 cites W2095345171 @default.
- W1985493485 cites W2096827547 @default.
- W1985493485 cites W2100338501 @default.
- W1985493485 cites W2101116356 @default.
- W1985493485 cites W2101462368 @default.
- W1985493485 cites W2102812687 @default.
- W1985493485 cites W2116387002 @default.
- W1985493485 cites W2130407647 @default.
- W1985493485 cites W2140962540 @default.
- W1985493485 cites W2145484503 @default.
- W1985493485 cites W2150749692 @default.
- W1985493485 cites W2151059333 @default.
- W1985493485 cites W2153811105 @default.
- W1985493485 cites W2155883881 @default.
- W1985493485 cites W2159469824 @default.
- W1985493485 cites W2167514450 @default.
- W1985493485 cites W2170822244 @default.
- W1985493485 cites W2287661533 @default.
- W1985493485 cites W2397904797 @default.
- W1985493485 cites W4249759827 @default.
- W1985493485 cites W4376453153 @default.
- W1985493485 doi "https://doi.org/10.1006/dbio.1999.9433" @default.
- W1985493485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10545239" @default.
- W1985493485 hasPublicationYear "1999" @default.
- W1985493485 type Work @default.
- W1985493485 sameAs 1985493485 @default.
- W1985493485 citedByCount "62" @default.
- W1985493485 countsByYear W19854934852012 @default.
- W1985493485 countsByYear W19854934852013 @default.
- W1985493485 countsByYear W19854934852014 @default.
- W1985493485 countsByYear W19854934852015 @default.
- W1985493485 countsByYear W19854934852016 @default.
- W1985493485 countsByYear W19854934852020 @default.
- W1985493485 countsByYear W19854934852021 @default.
- W1985493485 countsByYear W19854934852022 @default.
- W1985493485 countsByYear W19854934852023 @default.
- W1985493485 crossrefType "journal-article" @default.
- W1985493485 hasAuthorship W1985493485A5041517232 @default.
- W1985493485 hasAuthorship W1985493485A5063712240 @default.
- W1985493485 hasBestOaLocation W19854934851 @default.