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- W1985494623 abstract "Combination of non-cholestatic doses of manganese and bilirubin produced a dramatic fall in bile flow in rats that was dose dependent for bilirubin but not for manganese. However, the dose of manganese did influence, in a linear fashion, the period of time during which manganese-bilirubin (Mn-BR) cholestasis could be elicited. The protection afforded by sulfobromophthalein (BSP) was also studied. The magnitude of the protection seemed related to the amount of BSP remaining unexcreted at the time the bilirubin was injected. The relationship between the minimal protective dose of BSP and the dose of bilirubin was found to be linear and independent of manganese load. BSP appears to act on the bilirubin component of Mn-BR cholestasis, rather than on manganese." @default.
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- W1985494623 date "1979-06-01" @default.
- W1985494623 modified "2023-10-18" @default.
- W1985494623 title "Dose and time relationships in manganese-bilirubin cholestasis" @default.
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- W1985494623 doi "https://doi.org/10.1016/0041-008x(79)90249-7" @default.
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