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• W1985495870 abstract "The cholinergic receptor, nicotinic, alpha 4 (CHRNA4) gene encodes the neuronal nicotinic acetylcholine receptor alpha-4 subunit. Recent research has shown that a variation in CHRNA4 (rs1044396) affects attention and negative emotionality in normal adults. To determine the link between CHRNA4 variation and cognitive function/depressed mood, this study conducted a genotype–phenotype correlation analysis between the common CHRNA4:rs1044396 variant and several baseline parameters of cognition and depressed mood in 192 elderly male subjects without major psychiatric disorders or dementia. Study findings identified a significant link between the CHRNA4:rs1044396 polymorphism and depression and loneliness in the aged. Compared to carriers of at least one T-allele, carriers of the homozygous C/C genotype described themselves as more depressed and lonely. This is the first evidence which may implicate CHRNA4 in depressed emotions in the elderly." @default.
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• W1985495870 date "2011-11-23" @default.
• W1985495870 modified "2023-10-01" @default.
• W1985495870 title "Association of<i>CHRNA4</i>polymorphism with depression and loneliness in elderly males" @default.
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• W1985495870 doi "https://doi.org/10.1111/j.1601-183x.2011.00741.x" @default.
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