FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985496788> ?p ?o ?g. }

• W1985496788 endingPage "13" @default.
• W1985496788 startingPage "13" @default.
• W1985496788 abstract "T he genome sequence of Anopheles gambiae , the major mosquito vector of the malaria parasite Plasmodium falciparum , as well as analyses of its gene content and organization, are reported by several teams of investigators in this issue.[*][1] In addition, the sequence of the P. falciparum genome appears in this week's issue of Nature. The genomes of these two organisms, along with that of the human, provide a triad of critical genetic information relevant to all stages of the malaria transmission cycle and offer unprecedented opportunities to the scientific and public health communities engaged in the fight against malaria, a disease that takes a huge toll on humanity.Hundreds of millions of malaria cases and nearly three million malaria-related deaths are estimated to occur each year, predominantly in sub-Saharan Africa; however, more than 40% of the global population lives in countries where the disease is endemic. P. falciparum , the most lethal malaria parasite, is transmitted from one human to another by A. gambiae and other anopheline mosquito vectors. These insects are both efficient vehicles of malaria transmission and the Achilles' heel of the transmission cycle. It was primarily through vector control efforts that malaria was nearly eradicated in the middle of the 20th century in the Americas, India, and Asia. Even in Africa, where transmission is most intense, vector control remarkably reduced the burden of malaria. The formal World Health Organization eradication effort was stopped just short of its goal for many reasons, including problems with insecticides. An immediate goal for using the genomic sequence data for A. gambiae will be to identify targets for new and environmentally sound approaches to vector control.The availability of the genomic sequence data for each of the three organisms involved in malaria transmission will clarify the pathophysiologic relationships among human host, parasite, and vector. Among the many issues that can now be better addressed are the mechanisms of the range of refractoriness of the Anopheles species to Plasmodium , evasion of host immunity by the parasite, resistance to insecticides and antimalarial drugs, and identification of potential vaccine antigens. This research may allow targeting of control efforts or manipulation of genomes to reduce transmission or disease.The A. gambiae genome contains significant levels of genetic polymorphism that present a challenge for assembly as well as an unprecedented opportunity to address questions of population biology. Existing assembly paradigms have difficulty distinguishing repeated sequences from diverged haplotypes (see Holt et al. in this issue, p. [129][2]). The haplotype pattern provides insight into the ecological and evolutionary history of the organism, especially with regard to the various cytotypes that are considered to be incipient species. Single nucleotide polymorphisms and other markers offer the opportunity to study gene flow through mosquito populations and predict the likely spread of traits such as resistance and refractoriness.The bulk of the sequencing work for A. gambiae was completed in a public-private partnership that, although not the first of its kind, is another shining example of the possibilities of such programs. The high degree of cooperation and collaboration among all of the many researchers involved made this extraordinary achievement possible. Many additional partners, especially in malaria-endemic countries, will be required if we are to take full advantage of the potential fruits of this project.The genomic advances reported this week promise to foster new collaborations and a concordance of resources in malaria research. The challenge and opportunity for scientists is to use the freshness and excitement of these developments to forge new relationships, develop new tools, and ask the critical questions that must be answered if we are to reduce the enormous and unrelenting global burden of malaria. [1]: #fn-1 [2]: /lookup/doi/10.1126/science.1076181" @default.
• W1985496788 created "2016-06-24" @default.
• W1985496788 creator A5015442987 @default.
• W1985496788 creator A5018763815 @default.
• W1985496788 creator A5031736334 @default.
• W1985496788 creator A5043837752 @default.
• W1985496788 date "2002-10-04" @default.
• W1985496788 modified "2023-09-24" @default.
• W1985496788 title "<i>Anopheles gambiae</i> Genome: Completing the Malaria Triad" @default.
• W1985496788 doi "https://doi.org/10.1126/science.298.5591.13" @default.
• W1985496788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12364752" @default.
• W1985496788 hasPublicationYear "2002" @default.
• W1985496788 type Work @default.
• W1985496788 sameAs 1985496788 @default.
• W1985496788 citedByCount "20" @default.
• W1985496788 countsByYear W19854967882012 @default.
• W1985496788 countsByYear W19854967882013 @default.
• W1985496788 countsByYear W19854967882014 @default.
• W1985496788 countsByYear W19854967882015 @default.
• W1985496788 countsByYear W19854967882016 @default.
• W1985496788 countsByYear W19854967882017 @default.
• W1985496788 countsByYear W19854967882020 @default.
• W1985496788 crossrefType "journal-article" @default.
• W1985496788 hasAuthorship W1985496788A5015442987 @default.
• W1985496788 hasAuthorship W1985496788A5018763815 @default.
• W1985496788 hasAuthorship W1985496788A5031736334 @default.
• W1985496788 hasAuthorship W1985496788A5043837752 @default.
• W1985496788 hasBestOaLocation W19854967882 @default.
• W1985496788 hasConcept C104317684 @default.
• W1985496788 hasConcept C11171543 @default.
• W1985496788 hasConcept C141231307 @default.
• W1985496788 hasConcept C15744967 @default.
• W1985496788 hasConcept C176038584 @default.
• W1985496788 hasConcept C203014093 @default.
• W1985496788 hasConcept C2776802408 @default.
• W1985496788 hasConcept C2778048844 @default.
• W1985496788 hasConcept C2781375639 @default.
• W1985496788 hasConcept C54355233 @default.
• W1985496788 hasConcept C70721500 @default.
• W1985496788 hasConcept C78458016 @default.
• W1985496788 hasConcept C86803240 @default.
• W1985496788 hasConceptScore W1985496788C104317684 @default.
• W1985496788 hasConceptScore W1985496788C11171543 @default.
• W1985496788 hasConceptScore W1985496788C141231307 @default.
• W1985496788 hasConceptScore W1985496788C15744967 @default.
• W1985496788 hasConceptScore W1985496788C176038584 @default.
• W1985496788 hasConceptScore W1985496788C203014093 @default.
• W1985496788 hasConceptScore W1985496788C2776802408 @default.
• W1985496788 hasConceptScore W1985496788C2778048844 @default.
• W1985496788 hasConceptScore W1985496788C2781375639 @default.
• W1985496788 hasConceptScore W1985496788C54355233 @default.
• W1985496788 hasConceptScore W1985496788C70721500 @default.
• W1985496788 hasConceptScore W1985496788C78458016 @default.
• W1985496788 hasConceptScore W1985496788C86803240 @default.
• W1985496788 hasIssue "5591" @default.
• W1985496788 hasLocation W19854967881 @default.
• W1985496788 hasLocation W19854967882 @default.
• W1985496788 hasLocation W19854967883 @default.
• W1985496788 hasLocation W19854967884 @default.
• W1985496788 hasOpenAccess W1985496788 @default.
• W1985496788 hasPrimaryLocation W19854967881 @default.
• W1985496788 hasRelatedWork W1948183053 @default.
• W1985496788 hasRelatedWork W2040381857 @default.
• W1985496788 hasRelatedWork W2066580879 @default.
• W1985496788 hasRelatedWork W2131193520 @default.
• W1985496788 hasRelatedWork W2135880337 @default.
• W1985496788 hasRelatedWork W2302059504 @default.
• W1985496788 hasRelatedWork W2913361615 @default.
• W1985496788 hasRelatedWork W3008543655 @default.
• W1985496788 hasRelatedWork W4282973642 @default.
• W1985496788 hasRelatedWork W1821876253 @default.
• W1985496788 hasVolume "298" @default.
• W1985496788 isParatext "false" @default.
• W1985496788 isRetracted "false" @default.
• W1985496788 magId "1985496788" @default.
• W1985496788 workType "article" @default.