Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985498047> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1985498047 endingPage "110" @default.
- W1985498047 startingPage "106" @default.
- W1985498047 abstract "Variations in two genes of the tumour necrosis factor (TNF) alpha pathway have been implicated in the pathogenesis of autoimmune diseases: polymorphisms in the TNFRSF1A gene, encoding TNF receptor 1, showed significant association with MS in genomewide association scans, and variation in or near the TNFAIP3 gene, coding for a negative regulator of NFkB, was associated with MS, systemic lupus erythematosus, diabetes and rheumatoid arthritis. This study aimed at investigating association of MS with variation in the TNFRSF1A gene as well as in the TNFAIP3 gene region in an independent German case-control cohort. Four hundred and ninety-seven unrelated patients with MS and 878 healthy controls were genotyped with restriction enzyme digestion or TaqMan assays for three polymorphisms in the TNFRSF1A gene and seven in the region of the TNFAIP3 gene. Allele, genotype and haplotype frequencies were compared between cases and controls by chi-square testing. We found significant association of rs10499194, located in the intergenic region upstream of TNFAIP3, with MS (pc = 3.4 × 10(-4) ). Further, the intronic SNP rs1800693 in TNFRSF1A showed moderate association (pc = 0.033) with MS. In conclusion, evidence is accumulating that polymorphisms in both TNFAIP3 and TNFRSF1A genes play a role in MS pathogenesis. Additional studies are warranted to further elucidate the role of TNF pathway variation for MS development." @default.
- W1985498047 created "2016-06-24" @default.
- W1985498047 creator A5014446359 @default.
- W1985498047 creator A5024447480 @default.
- W1985498047 creator A5025452509 @default.
- W1985498047 creator A5055426639 @default.
- W1985498047 creator A5068835941 @default.
- W1985498047 creator A5074554078 @default.
- W1985498047 date "2015-02-12" @default.
- W1985498047 modified "2023-10-05" @default.
- W1985498047 title "Association of<i>TNFAIP3</i>and<i>TNFRSF1A</i>variation with multiple sclerosis in a German case-control cohort" @default.
- W1985498047 cites W1765113427 @default.
- W1985498047 cites W1872841669 @default.
- W1985498047 cites W1963819091 @default.
- W1985498047 cites W2002792886 @default.
- W1985498047 cites W2015516540 @default.
- W1985498047 cites W2037368171 @default.
- W1985498047 cites W2039462791 @default.
- W1985498047 cites W2042342193 @default.
- W1985498047 cites W2055514573 @default.
- W1985498047 cites W2067284134 @default.
- W1985498047 cites W2069606030 @default.
- W1985498047 cites W2073167340 @default.
- W1985498047 cites W2103502637 @default.
- W1985498047 cites W2106624849 @default.
- W1985498047 cites W2121080849 @default.
- W1985498047 cites W2132991384 @default.
- W1985498047 cites W2137277521 @default.
- W1985498047 cites W2139982131 @default.
- W1985498047 cites W2148430942 @default.
- W1985498047 cites W2162530578 @default.
- W1985498047 cites W2324384121 @default.
- W1985498047 doi "https://doi.org/10.1111/iji.12183" @default.
- W1985498047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25684197" @default.
- W1985498047 hasPublicationYear "2015" @default.
- W1985498047 type Work @default.
- W1985498047 sameAs 1985498047 @default.
- W1985498047 citedByCount "18" @default.
- W1985498047 countsByYear W19854980472017 @default.
- W1985498047 countsByYear W19854980472018 @default.
- W1985498047 countsByYear W19854980472019 @default.
- W1985498047 countsByYear W19854980472020 @default.
- W1985498047 countsByYear W19854980472021 @default.
- W1985498047 countsByYear W19854980472022 @default.
- W1985498047 crossrefType "journal-article" @default.
- W1985498047 hasAuthorship W1985498047A5014446359 @default.
- W1985498047 hasAuthorship W1985498047A5024447480 @default.
- W1985498047 hasAuthorship W1985498047A5025452509 @default.
- W1985498047 hasAuthorship W1985498047A5055426639 @default.
- W1985498047 hasAuthorship W1985498047A5068835941 @default.
- W1985498047 hasAuthorship W1985498047A5074554078 @default.
- W1985498047 hasConcept C104317684 @default.
- W1985498047 hasConcept C135763542 @default.
- W1985498047 hasConcept C139275648 @default.
- W1985498047 hasConcept C153209595 @default.
- W1985498047 hasConcept C180754005 @default.
- W1985498047 hasConcept C186413461 @default.
- W1985498047 hasConcept C197754878 @default.
- W1985498047 hasConcept C203014093 @default.
- W1985498047 hasConcept C2780942790 @default.
- W1985498047 hasConcept C54355233 @default.
- W1985498047 hasConcept C71924100 @default.
- W1985498047 hasConcept C86803240 @default.
- W1985498047 hasConceptScore W1985498047C104317684 @default.
- W1985498047 hasConceptScore W1985498047C135763542 @default.
- W1985498047 hasConceptScore W1985498047C139275648 @default.
- W1985498047 hasConceptScore W1985498047C153209595 @default.
- W1985498047 hasConceptScore W1985498047C180754005 @default.
- W1985498047 hasConceptScore W1985498047C186413461 @default.
- W1985498047 hasConceptScore W1985498047C197754878 @default.
- W1985498047 hasConceptScore W1985498047C203014093 @default.
- W1985498047 hasConceptScore W1985498047C2780942790 @default.
- W1985498047 hasConceptScore W1985498047C54355233 @default.
- W1985498047 hasConceptScore W1985498047C71924100 @default.
- W1985498047 hasConceptScore W1985498047C86803240 @default.
- W1985498047 hasIssue "2" @default.
- W1985498047 hasLocation W19854980471 @default.
- W1985498047 hasLocation W19854980472 @default.
- W1985498047 hasOpenAccess W1985498047 @default.
- W1985498047 hasPrimaryLocation W19854980471 @default.
- W1985498047 hasRelatedWork W1901150897 @default.
- W1985498047 hasRelatedWork W1966708416 @default.
- W1985498047 hasRelatedWork W1994630386 @default.
- W1985498047 hasRelatedWork W2021538970 @default.
- W1985498047 hasRelatedWork W2072704524 @default.
- W1985498047 hasRelatedWork W2258660676 @default.
- W1985498047 hasRelatedWork W2283861756 @default.
- W1985498047 hasRelatedWork W2327017833 @default.
- W1985498047 hasRelatedWork W2360977025 @default.
- W1985498047 hasRelatedWork W860817473 @default.
- W1985498047 hasVolume "42" @default.
- W1985498047 isParatext "false" @default.
- W1985498047 isRetracted "false" @default.
- W1985498047 magId "1985498047" @default.
- W1985498047 workType "article" @default.