FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985506024> ?p ?o ?g. }

• W1985506024 endingPage "127" @default.
• W1985506024 startingPage "121" @default.
• W1985506024 abstract "Cathepsins L and B are lysosomal cysteine proteinases whose activities and cellular location are altered in many types of cancers and cancer cell lines. Cathepsins L and B play an unspecified role in cancer invasion and metastasis. The purpose of our study was to determine whether cathepsins L and B are important for the ability of two prostate cancer cell lines, PC3 and DU 145, to invade the basement membrane-like preparation, Matrigel®. Exposure of PC3 and DU145 to the irreversible cysteine proteinase inhibitor, E64, decreases the invasive ability of DU145, but not PC3. PC3 and DU145 were treated with the phorbol ester analogue, phorbol 12-myristate 13-acetate (PMA), a known tumor promoter that activates protein kinase C and contributes to the metastatic phenotype. PMA increased secreted cathepsin L+B activity and the invasive ability of PC3 and DU145; co-exposure to E64 and PMA decreased both cathepsin L+B activity and invasion. We conclude that DU145 requires cathepsin L+B activity more than PC3 for the invasion of the Matrigel®. When the amount of secreted cathepsin L+B activity is increased by PMA treatment, however, PC3 becomes dependent on cathepsin L+B for invasion. Our study demonstrates that modulation of the amount of secreted cathepsin L+B activity influences the invasive phenotype of PC3 and DU145." @default.
• W1985506024 created "2016-06-24" @default.
• W1985506024 creator A5053320161 @default.
• W1985506024 creator A5063113664 @default.
• W1985506024 creator A5075520973 @default.
• W1985506024 date "2004-06-01" @default.
• W1985506024 modified "2023-09-24" @default.
• W1985506024 title "Matrigel® invasion by the prostate cancer cell lines, PC3 and DU145, and cathepsin L+B activity" @default.
• W1985506024 cites W1484675846 @default.
• W1985506024 cites W1691503547 @default.
• W1985506024 cites W1775749144 @default.
• W1985506024 cites W1812339273 @default.
• W1985506024 cites W1970477648 @default.
• W1985506024 cites W1977096127 @default.
• W1985506024 cites W2030303876 @default.
• W1985506024 cites W2042078698 @default.
• W1985506024 cites W2048861137 @default.
• W1985506024 cites W2055930652 @default.
• W1985506024 cites W2059572890 @default.
• W1985506024 cites W2068023718 @default.
• W1985506024 cites W2073317729 @default.
• W1985506024 cites W2074894180 @default.
• W1985506024 cites W2081105252 @default.
• W1985506024 cites W2087827778 @default.
• W1985506024 cites W2122421028 @default.
• W1985506024 cites W2131669932 @default.
• W1985506024 cites W2151493707 @default.
• W1985506024 cites W2155441778 @default.
• W1985506024 cites W2165155252 @default.
• W1985506024 cites W4229714492 @default.
• W1985506024 doi "https://doi.org/10.1080/10520290400010572" @default.
• W1985506024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15621884" @default.
• W1985506024 hasPublicationYear "2004" @default.
• W1985506024 type Work @default.
• W1985506024 sameAs 1985506024 @default.
• W1985506024 citedByCount "28" @default.
• W1985506024 countsByYear W19855060242012 @default.
• W1985506024 countsByYear W19855060242013 @default.
• W1985506024 countsByYear W19855060242014 @default.
• W1985506024 countsByYear W19855060242015 @default.
• W1985506024 countsByYear W19855060242016 @default.
• W1985506024 countsByYear W19855060242017 @default.
• W1985506024 countsByYear W19855060242018 @default.
• W1985506024 countsByYear W19855060242019 @default.
• W1985506024 countsByYear W19855060242020 @default.
• W1985506024 countsByYear W19855060242021 @default.
• W1985506024 countsByYear W19855060242022 @default.
• W1985506024 crossrefType "journal-article" @default.
• W1985506024 hasAuthorship W1985506024A5053320161 @default.
• W1985506024 hasAuthorship W1985506024A5063113664 @default.
• W1985506024 hasAuthorship W1985506024A5075520973 @default.
• W1985506024 hasConcept C121608353 @default.
• W1985506024 hasConcept C1491633281 @default.
• W1985506024 hasConcept C153911025 @default.
• W1985506024 hasConcept C167844969 @default.
• W1985506024 hasConcept C181199279 @default.
• W1985506024 hasConcept C185592680 @default.
• W1985506024 hasConcept C2776438761 @default.
• W1985506024 hasConcept C2778608917 @default.
• W1985506024 hasConcept C2779723316 @default.
• W1985506024 hasConcept C2780034444 @default.
• W1985506024 hasConcept C28021979 @default.
• W1985506024 hasConcept C502942594 @default.
• W1985506024 hasConcept C54355233 @default.
• W1985506024 hasConcept C55493867 @default.
• W1985506024 hasConcept C86803240 @default.
• W1985506024 hasConcept C96232424 @default.
• W1985506024 hasConceptScore W1985506024C121608353 @default.
• W1985506024 hasConceptScore W1985506024C1491633281 @default.
• W1985506024 hasConceptScore W1985506024C153911025 @default.
• W1985506024 hasConceptScore W1985506024C167844969 @default.
• W1985506024 hasConceptScore W1985506024C181199279 @default.
• W1985506024 hasConceptScore W1985506024C185592680 @default.
• W1985506024 hasConceptScore W1985506024C2776438761 @default.
• W1985506024 hasConceptScore W1985506024C2778608917 @default.
• W1985506024 hasConceptScore W1985506024C2779723316 @default.
• W1985506024 hasConceptScore W1985506024C2780034444 @default.
• W1985506024 hasConceptScore W1985506024C28021979 @default.
• W1985506024 hasConceptScore W1985506024C502942594 @default.
• W1985506024 hasConceptScore W1985506024C54355233 @default.
• W1985506024 hasConceptScore W1985506024C55493867 @default.
• W1985506024 hasConceptScore W1985506024C86803240 @default.
• W1985506024 hasConceptScore W1985506024C96232424 @default.
• W1985506024 hasIssue "3-4" @default.
• W1985506024 hasLocation W19855060241 @default.
• W1985506024 hasLocation W19855060242 @default.
• W1985506024 hasOpenAccess W1985506024 @default.
• W1985506024 hasPrimaryLocation W19855060241 @default.
• W1985506024 hasRelatedWork W1967978378 @default.
• W1985506024 hasRelatedWork W1985506024 @default.
• W1985506024 hasRelatedWork W1999961572 @default.
• W1985506024 hasRelatedWork W2055199576 @default.
• W1985506024 hasRelatedWork W2087827778 @default.
• W1985506024 hasRelatedWork W2131669932 @default.
• W1985506024 hasRelatedWork W2139275843 @default.
• W1985506024 hasRelatedWork W33200098 @default.
• W1985506024 hasRelatedWork W954505368 @default.
• W1985506024 hasRelatedWork W2518161626 @default.

• next