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• W1985508977 abstract "Abstract Papulaspora immersa H. H. Hotson was isolated from roots and leaves of Smallanthus sonchifolius ( Poepp. and Endl. ) H. Rob. (Asteraceae), traditionally known as Yacon. The fungus was cultured in rice, and, from the AcOEt fraction, 14 compounds were isolated. Among them, (22 E ,24 R )‐8,14‐epoxyergosta‐4,22‐diene‐3,6‐dione ( 4 ), 2,3‐epoxy‐1,2,3,4‐tetrahydronaphthalene‐ c ‐1, c ‐4,8‐triol ( 10 ), and the chromone papulasporin ( 13 ) were new secondary metabolites. The spectral data of the known natural products were compared with the literature data, and their structures were established as the (24 R )‐stigmast‐4‐en‐3‐one ( 1 ), 24‐methylenecycloartan‐3 β ‐ol ( 2 ), (22 E ,24 R )‐ergosta‐4,6,8(14),22‐tetraen‐3‐one ( 3 ), (−)‐(3 R ,4 R )‐4‐hydroxymellein ( 5 ), (−)‐(3 R )‐5‐hydroxymellein ( 6 ), 6,8‐dihydroxy‐3‐methylisocoumarin ( 7 ), (−)‐(4 S )‐4,8‐dihydroxy‐ α ‐tetralone ( 8 ), naphthalene‐1,8‐diol ( 9 ), 6,7,8‐trihydroxy‐3‐methylisocoumarin ( 11 ), 7‐hydroxy‐2,5‐dimethylchromone ( 12 ), and tyrosol ( 14 ). Compound 4 showed the highest cytotoxic activity against the human tumor cell lines MDA‐MB435 (melanoma), HCT‐8 (colon), SF295 (glioblastoma), and HL‐60 (promyelocytic leukemia), with IC 50 values of 3.3, 14.7, 5.0 and 1.6 μ M , respectively. Strong synergistic effects were also observed with compound 5 and some of the isolated steroidal compounds." @default.
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• W1985508977 date "2010-12-01" @default.
• W1985508977 modified "2023-10-11" @default.
• W1985508977 title "Chemical Constituents of Papulaspora immersa, an Endophyte from Smallanthus sonchifolius (Asteraceae), and Their Cytotoxic Activity" @default.
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• W1985508977 doi "https://doi.org/10.1002/cbdv.201000011" @default.
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