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- W1985522546 abstract "Structural studies on proteins have placed certain molecules with related functions in extended families with a possible common ancestor. The immunoglobulin family is one such grouping: among its putative members are Thy-1, C-reactive protein, β2-microglobulin, and MHC class-I and class-II products. Here John Marchalonis and his colleagues discuss new computer analyses of sequence data and serological studies which argue against the inclusion of Thy-1 and C-reactive protein in the immunoglobulin family. The sequence data suggest, however, that domains may be shared by recognition molecules with different evolutionary histories and that immunoglobulin and non-immunoglobulin molecules may cross-react serologically because they have ‘minigenes’ in common." @default.
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- W1985522546 date "1984-05-01" @default.
- W1985522546 modified "2023-10-18" @default.
- W1985522546 title "Probing the boundaries of the extended immunoglobulin family of recognition molecules: jumping domains, convergence and minigenes" @default.
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- W1985522546 doi "https://doi.org/10.1016/0167-5699(84)90236-6" @default.
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