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- W1985528170 abstract "CD8+ T cells have been shown to be required for acute resistance to infection with the protozoan parasite, Trypanosoma cruzi, the causative agent of Chagas' disease. However, to date, the mechanism by which CD8+ T cells mediate protection in vivo has not been determined. While CD8+ T cells can exhibit cytolytic function, they also secrete cytokines such as IFN-gamma, which is known to mediate protection against T. cruzi infections. To determine whether cytolysis is an important effector function in vivo, we have compared outcomes of T. cruzi infection in normal and perforin-deficient mice. Our results indicate that while perforin-dependent cytolytic mechanisms clearly make a major contribution to acute resistance to T. cruzi infection, this contribution may be strain and challenge dose-dependent, since perforin-deficient mice challenged with lower doses of a less virulent strain survived and were subsequently resistant to challenge with virulent organisms. In vivo depletion studies demonstrated that survival of perforin-deficient mice challenged with low doses of T. cruzi requires both CD4+ and CD8+ T cells and is dependent on IFN-gamma secretion. These studies document the participation of both perforin-dependent cytotoxic and perforin-independent, IFN-gamma-dependent immune mechanisms in acute resistance to T. cruzi infection." @default.
- W1985528170 created "2016-06-24" @default.
- W1985528170 creator A5006592733 @default.
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- W1985528170 date "2000-04-01" @default.
- W1985528170 modified "2023-09-27" @default.
- W1985528170 title "Trypanosoma cruzi: Roles for Perforin-Dependent and Perforin-Independent Immune Mechanisms in Acute Resistance" @default.
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- W1985528170 doi "https://doi.org/10.1006/expr.2000.4498" @default.
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