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• W1985570823 abstract "A major thrust in type 1 diabetes research is stopping the destruction of beta cells that leads to type 1 diabetes. Research over the past 30 years has defined genetic factors and evidence of autoimmunity that have led to the development of robust prediction models in those at high risk for type 1 diabetes. The ability to identify those at risk and the development of new agents and of collaborative research networks has led to multiple trials aimed at preventing beta cell loss. Trials at all stages of beta cell loss have been conducted: primary prevention (prior to the development of autoimmunity); secondary prevention (after autoantibodies are found) and tertiary prevention (intervening after diagnosis to maintain remaining beta cells). Studies have shown mixed results; evidence of maintained insulin secretion after the time of diagnosis has been described in a number of studies, and primary and secondary prevention is proving to be elusive. Much has been learned from the increasing number of studies in the field in terms of network creation, study design and choice of intervention that will facilitate new avenues of investigation." @default.
• W1985570823 created "2016-06-24" @default.
• W1985570823 creator A5068398869 @default.
• W1985570823 date "2014-08-01" @default.
• W1985570823 modified "2023-10-16" @default.
• W1985570823 title "Trials in the Prevention of Type 1 Diabetes: Current and Future" @default.
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• W1985570823 doi "https://doi.org/10.1016/j.jcjd.2014.05.004" @default.
• W1985570823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4133140" @default.
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