FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985583055> ?p ?o ?g. }

• W1985583055 endingPage "e0116887" @default.
• W1985583055 startingPage "e0116887" @default.
• W1985583055 abstract "Autologous stem cell transplantation (ASCT) is a feasible procedure for human immunodeficiency virus-1 (HIV-1) lymphoma patients, whose underlying disease and intrinsic HIV-1- and ASCT-associated immunodeficiency might increase the risk for γ-herpesvirus load persistence and/or reactivation. We evaluated this hypothesis by investigating the levels of Epstein-Barr virus (EBV)- and Kaposi sarcoma-associated herpesvirus (KSHV)-DNA levels in the peripheral blood of 22 HIV-1-associated lymphoma patients during ASCT, highlighting their relationship with γ-herpesvirus lymphoma status, immunological parameters, and clinical events. EBV-DNA was detected in the pre-treatment plasma and peripheral blood mononuclear cells (PBMCs) of 12 (median 12135 copies/mL) and 18 patients (median 417 copies/106 PBMCs), respectively; the values in the two compartments were correlated (r = 0.77, p = 0.0001). Only EBV-positive lymphomas showed detectable levels of plasma EBV-DNA. After debulking chemotherapy, plasma EBV-DNA was associated with lymphoma chemosensitivity (p = 0.03) and a significant higher mortality risk by multivariate Cox analysis adjusted for EBV-lymphoma status (HR, 10.46, 95% CI, 1.11–98.32, p = 0.04). After infusion, EBV-DNA was detectable in five EBV-positive lymphoma patients who died within six months. KSHV-DNA load was positive in only one patient, who died from primary effusion lymphoma. Fluctuations in levels of KSHV-DNA reflected the patient’s therapy and evolution of his underlying lymphoma. Other γ-herpesvirus-associated malignancies, such as multicentric Castleman disease and Kaposi sarcoma, or end-organ complications after salvage treatment were not found. Overall, these findings suggest a prognostic and predictive value of EBV-DNA and KSHV-DNA, the monitoring of which could be a simple, complementary tool for the management of γ-herpesvirus-positive lymphomas in HIV-1 patients submitted to ASCT." @default.
• W1985583055 created "2016-06-24" @default.
• W1985583055 creator A5003750946 @default.
• W1985583055 creator A5026491986 @default.
• W1985583055 creator A5031805909 @default.
• W1985583055 creator A5037367152 @default.
• W1985583055 creator A5038699632 @default.
• W1985583055 creator A5038744631 @default.
• W1985583055 creator A5045745778 @default.
• W1985583055 creator A5047379524 @default.
• W1985583055 creator A5052342075 @default.
• W1985583055 creator A5071643794 @default.
• W1985583055 creator A5071674836 @default.
• W1985583055 creator A5077113935 @default.
• W1985583055 creator A5086937257 @default.
• W1985583055 creator A5087387309 @default.
• W1985583055 creator A5089607807 @default.
• W1985583055 date "2015-02-10" @default.
• W1985583055 modified "2023-10-15" @default.
• W1985583055 title "γ-Herpesvirus Load as Surrogate Marker of Early Death in HIV-1 Lymphoma Patients Submitted to High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation" @default.
• W1985583055 cites W1491144410 @default.
• W1985583055 cites W1497400248 @default.
• W1985583055 cites W1533340695 @default.
• W1985583055 cites W1579217101 @default.
• W1985583055 cites W1912693401 @default.
• W1985583055 cites W1967278331 @default.
• W1985583055 cites W1968860073 @default.
• W1985583055 cites W1971453711 @default.
• W1985583055 cites W1977177626 @default.
• W1985583055 cites W1977809195 @default.
• W1985583055 cites W1978253803 @default.
• W1985583055 cites W1985199344 @default.
• W1985583055 cites W1987728229 @default.
• W1985583055 cites W1994887878 @default.
• W1985583055 cites W1999287802 @default.
• W1985583055 cites W2010686257 @default.
• W1985583055 cites W2013838050 @default.
• W1985583055 cites W2015811107 @default.
• W1985583055 cites W2016776292 @default.
• W1985583055 cites W2022268014 @default.
• W1985583055 cites W2024911372 @default.
• W1985583055 cites W2025550138 @default.
• W1985583055 cites W2026817489 @default.
• W1985583055 cites W2045239703 @default.
• W1985583055 cites W2046690772 @default.
• W1985583055 cites W2051436390 @default.
• W1985583055 cites W2053361200 @default.
• W1985583055 cites W2067659752 @default.
• W1985583055 cites W2079491300 @default.
• W1985583055 cites W2083755283 @default.
• W1985583055 cites W2086310342 @default.
• W1985583055 cites W2090977926 @default.
• W1985583055 cites W2091896991 @default.
• W1985583055 cites W2092502353 @default.
• W1985583055 cites W2094522830 @default.
• W1985583055 cites W2098563518 @default.
• W1985583055 cites W2100638063 @default.
• W1985583055 cites W2100870126 @default.
• W1985583055 cites W2104844692 @default.
• W1985583055 cites W2106286457 @default.
• W1985583055 cites W2114103196 @default.
• W1985583055 cites W2119891686 @default.
• W1985583055 cites W2123281703 @default.
• W1985583055 cites W2124529510 @default.
• W1985583055 cites W2129129940 @default.
• W1985583055 cites W2129309356 @default.
• W1985583055 cites W2131671733 @default.
• W1985583055 cites W2144718251 @default.
• W1985583055 cites W2158151869 @default.
• W1985583055 cites W2158220738 @default.
• W1985583055 cites W2158874326 @default.
• W1985583055 cites W2331856563 @default.
• W1985583055 cites W324612156 @default.
• W1985583055 cites W4293241248 @default.
• W1985583055 doi "https://doi.org/10.1371/journal.pone.0116887" @default.
• W1985583055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4323102" @default.
• W1985583055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25668032" @default.
• W1985583055 hasPublicationYear "2015" @default.
• W1985583055 type Work @default.
• W1985583055 sameAs 1985583055 @default.
• W1985583055 citedByCount "4" @default.
• W1985583055 countsByYear W19855830552015 @default.
• W1985583055 countsByYear W19855830552017 @default.
• W1985583055 countsByYear W19855830552018 @default.
• W1985583055 countsByYear W19855830552021 @default.
• W1985583055 crossrefType "journal-article" @default.
• W1985583055 hasAuthorship W1985583055A5003750946 @default.
• W1985583055 hasAuthorship W1985583055A5026491986 @default.
• W1985583055 hasAuthorship W1985583055A5031805909 @default.
• W1985583055 hasAuthorship W1985583055A5037367152 @default.
• W1985583055 hasAuthorship W1985583055A5038699632 @default.
• W1985583055 hasAuthorship W1985583055A5038744631 @default.
• W1985583055 hasAuthorship W1985583055A5045745778 @default.
• W1985583055 hasAuthorship W1985583055A5047379524 @default.
• W1985583055 hasAuthorship W1985583055A5052342075 @default.
• W1985583055 hasAuthorship W1985583055A5071643794 @default.
• W1985583055 hasAuthorship W1985583055A5071674836 @default.
• W1985583055 hasAuthorship W1985583055A5077113935 @default.

• next