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- W1985586405 abstract "Abstract Hydrocortisone inhibits PHA-induced lymphocyte stimulation by reducing the number of cells entering G1-phase and by slowing the volume growth rate during the first 24 h of culture: the kinetics of cellular recruitment is unmodified. This inhibition has a linear log-dose response curve and there is marked intersubject variation in normal adults. Pre-incubation of the cells with hydrocortisone greatly potentiates its inhibitory effect: when added after the start of PHA stimulation, hydrocortisone becomes progressively less effective until it has lost most of its activity by 5 h, even though the cells do not show any microscopic evidence of having entered the G1-phase at that time. The experiments have elucidated the mode of action of hydrocortisone inhibition on the early stages of PHA-induced lymphocyte stimulation and shown an unexpectedly large intersubject variation in responsiveness that might have therapeutic significance. The methods that have been employed could be adapted for clinical monitoring of the immunosuppressive effect of glucocorticoids in individual patients and for screening synthetic steroids for glucocorticoid activity." @default.
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- W1985586405 date "1981-01-01" @default.
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- W1985586405 title "Dose-related depression of pha-induced stimulation of human lymphocytes by hydrocortisone" @default.
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- W1985586405 doi "https://doi.org/10.1016/0192-0561(81)90042-4" @default.
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