FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985593903> ?p ?o ?g. }

• W1985593903 endingPage "194" @default.
• W1985593903 startingPage "185" @default.
• W1985593903 abstract "The sympathetic nervous system regulates immune responses in part through direct innervation of lymphoid organs. Recent data indicate that viral infections can alter the structure of lymph node innervation. To determine the molecular mechanisms underlying sympathetic denervation during Simian Immunodeficiency Virus (SIV) infection, we assessed the expression of neurotrophic factors and neuromodulatory cytokines within lymph nodes from experimentally infected rhesus macaques. Transcription of nerve growth factor (NGF), brain-derived neurotropic factor (BDNF) and neurotrophin-4 (NT4) decreased significantly in vivo during chronic SIV infection, whereas expression of the neuro-inhibitory cytokine interferon-γ (IFNγ) was up-regulated. Acute SIV infection of macaque leukocytes in vitro induced similar changes in the expression of neurotrophic and neuro-inhibitory factors, indicative of an innate immune response. Statistical mediation analyses of data from in vivo lymph node gene expression suggested that coordinated changes in expression of multiple neuromodulatory factors may contribute to SIV-induced depletion of catecholaminergic varicosities within lymphoid tissue. Given previous evidence that lymph node catecholaminergic varicosities can enhance SIV replication in vivo, these results are consistent with the hypothesis that reduced expression of neurotrophic factors during infection could constitute a neurobiological component of the innate immune response to viral infection." @default.
• W1985593903 created "2016-06-24" @default.
• W1985593903 creator A5010854673 @default.
• W1985593903 creator A5011136538 @default.
• W1985593903 creator A5024960678 @default.
• W1985593903 creator A5049613399 @default.
• W1985593903 creator A5059229018 @default.
• W1985593903 creator A5074983770 @default.
• W1985593903 date "2008-02-01" @default.
• W1985593903 modified "2023-09-25" @default.
• W1985593903 title "SIV infection decreases sympathetic innervation of primate lymph nodes: The role of neurotrophins" @default.
• W1985593903 cites W1524241997 @default.
• W1985593903 cites W1531884080 @default.
• W1985593903 cites W1817124372 @default.
• W1985593903 cites W1855182844 @default.
• W1985593903 cites W1884792319 @default.
• W1985593903 cites W1944137027 @default.
• W1985593903 cites W1948168563 @default.
• W1985593903 cites W1965794762 @default.
• W1985593903 cites W1967432768 @default.
• W1985593903 cites W1971440513 @default.
• W1985593903 cites W1974280453 @default.
• W1985593903 cites W1974863444 @default.
• W1985593903 cites W1993668617 @default.
• W1985593903 cites W1998616887 @default.
• W1985593903 cites W2006669841 @default.
• W1985593903 cites W2007401191 @default.
• W1985593903 cites W2008511207 @default.
• W1985593903 cites W2008598172 @default.
• W1985593903 cites W2018393555 @default.
• W1985593903 cites W2023202831 @default.
• W1985593903 cites W2027674121 @default.
• W1985593903 cites W2035072797 @default.
• W1985593903 cites W2050956734 @default.
• W1985593903 cites W2062444650 @default.
• W1985593903 cites W2063695629 @default.
• W1985593903 cites W2071648980 @default.
• W1985593903 cites W2076555051 @default.
• W1985593903 cites W2082203575 @default.
• W1985593903 cites W2084120087 @default.
• W1985593903 cites W2090329397 @default.
• W1985593903 cites W2118660831 @default.
• W1985593903 cites W2120658378 @default.
• W1985593903 cites W2121818146 @default.
• W1985593903 cites W2122365943 @default.
• W1985593903 cites W2131545168 @default.
• W1985593903 cites W2139722295 @default.
• W1985593903 cites W2145890850 @default.
• W1985593903 cites W2151606813 @default.
• W1985593903 cites W2156292862 @default.
• W1985593903 cites W2158688471 @default.
• W1985593903 cites W2164406482 @default.
• W1985593903 cites W2169800968 @default.
• W1985593903 cites W4253566969 @default.
• W1985593903 cites W4292811746 @default.
• W1985593903 cites W4327766731 @default.
• W1985593903 cites W70432922 @default.
• W1985593903 cites W79466244 @default.
• W1985593903 doi "https://doi.org/10.1016/j.bbi.2007.07.008" @default.
• W1985593903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2254209" @default.
• W1985593903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17870298" @default.
• W1985593903 hasPublicationYear "2008" @default.
• W1985593903 type Work @default.
• W1985593903 sameAs 1985593903 @default.
• W1985593903 citedByCount "22" @default.
• W1985593903 countsByYear W19855939032013 @default.
• W1985593903 countsByYear W19855939032016 @default.
• W1985593903 countsByYear W19855939032017 @default.
• W1985593903 countsByYear W19855939032018 @default.
• W1985593903 countsByYear W19855939032019 @default.
• W1985593903 countsByYear W19855939032020 @default.
• W1985593903 countsByYear W19855939032021 @default.
• W1985593903 countsByYear W19855939032022 @default.
• W1985593903 crossrefType "journal-article" @default.
• W1985593903 hasAuthorship W1985593903A5010854673 @default.
• W1985593903 hasAuthorship W1985593903A5011136538 @default.
• W1985593903 hasAuthorship W1985593903A5024960678 @default.
• W1985593903 hasAuthorship W1985593903A5049613399 @default.
• W1985593903 hasAuthorship W1985593903A5059229018 @default.
• W1985593903 hasAuthorship W1985593903A5074983770 @default.
• W1985593903 hasBestOaLocation W19855939032 @default.
• W1985593903 hasConcept C160539049 @default.
• W1985593903 hasConcept C169760540 @default.
• W1985593903 hasConcept C170493617 @default.
• W1985593903 hasConcept C203014093 @default.
• W1985593903 hasConcept C2775894120 @default.
• W1985593903 hasConcept C2776824294 @default.
• W1985593903 hasConcept C2777995582 @default.
• W1985593903 hasConcept C2778690821 @default.
• W1985593903 hasConcept C2778950215 @default.
• W1985593903 hasConcept C2780849966 @default.
• W1985593903 hasConcept C55493867 @default.
• W1985593903 hasConcept C86803240 @default.
• W1985593903 hasConcept C8891405 @default.
• W1985593903 hasConcept C92020748 @default.
• W1985593903 hasConceptScore W1985593903C160539049 @default.
• W1985593903 hasConceptScore W1985593903C169760540 @default.
• W1985593903 hasConceptScore W1985593903C170493617 @default.

• next