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• W1985602372 abstract "Key pecking by 6 pigeons was maintained by a fixed‐ratio 30 schedule of food presentation while body weights were 80% of free‐feeding weights. Acute administration of cocaine (0.3 to 13.0 mg/kg, i.m.) dose‐dependently decreased response rates. Dose‐effect curves were shifted to the right when 3 of the 6 pigeons were maintained at 70% of free‐feeding weights and were shifted to the left when the other 3 pigeons were maintained at 90% of free‐feeding weights. Then a dose of cocaine that initially decreased response rates by more than 95% of control rates was administered before each daily session. Comparable degrees of tolerance to these rate‐decreasing effects developed in the two groups. The rate at which responding recovered was relatively rapid for pigeons in the 70% free‐feeding‐weight group and was slower for 2 of the 3 pigeons in the 90% free‐feeding‐weight group. When body weights were then increased from 70% to 80% or were decreased from 90% to 80% of free‐feeding weight, performance was disrupted initially only for pigeons whose weight went from 70% to 80% of free feeding. In the present experiment the degree of deprivation may have indirectly influenced the degree of tolerance that developed to cocaine's response rate‐decreasing effects because it directly influenced the dose chosen to be administered chronically. The degree of deprivation appeared to have a more direct influence on the rate at which tolerance developed." @default.
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• W1985602372 date "1996-01-01" @default.
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• W1985602372 title "COCAINE AND FOOD DEPRIVATION: EFFECTS ON FOOD‐REINFORCED FIXED‐RATIO PERFORMANCE IN PIGEONS" @default.
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• W1985602372 doi "https://doi.org/10.1901/jeab.1996.65-145" @default.
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