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- W1985603130 abstract "The effect of ascorbic acid and Fe2+ on p-aminohippurate accumulation by rat kidney slices was examined. Ascorbic acid and Fe2+ promoted lipid peroxidation of rat renal cortical slices was found to be dose related. Moreover, ascorbic acid (1.0 mM) and Fe2+ (0.4 mM) increased tissue water and decreased the accumulation of p-aminohippurate. The addition of N,N'-diphenyl-p-phenylenediamine (antioxidant) at the concentration of 1 x 10(-6) M recovered the accumulation of p-aminohippurate by about 43%. The apparent Km of p-aminohippurate uptake was increased by ascorbic acid and Fe2+ with no change in the apparent V. These data suggest that ascorbic acid and Fe2+ can cause a significant alteration in p-aminohippurate and water transport of renal cortical slices and that these effects may be, at least, partly due to the lipid peroxidative action of ascorbic acid and Fe2+." @default.
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- W1985603130 date "1981-01-01" @default.
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- W1985603130 title "Effect of ascorbic acid and ferrous iron on P-aminohippurate accumulation by rat kidney cortical slices." @default.
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- W1985603130 doi "https://doi.org/10.1254/jjp.31.1013" @default.
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