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• W1985604322 abstract "The ability to measure brain tissue chemistry has led to valuable information regarding pathophysiological changes in patients with traumatic brain injury (TBI). Over the last few years, the focus has been on monitoring changes in brain tissue oxygen to determine thresholds of ischemia that affect outcome. However, the variability of this measurement suggests that it may not be a robust method. We have therefore investigated the relationship of brain tissue pH (pHb) and outcome in patients with TBI. We retrospectively analyzed prospectively collected data of 38 patients admitted to the Neurosciences Critical Care Unit with TBI between 1998 and 2003, and who had a multiparameter tissue gas sensor inserted into the brain. All patients were managed using an evidence-based protocol targeting CPP > 70 mm Hg. Physiological variables were averaged over 4 min and analyzed using a generalized least squares random effects model to determine the temporal profile of pHb and its association with outcome. Median (IQR) minimum pHb was 7.00 (6.89, 7.08), median (IQR) maximum pHb was 7.25 (7.18, 7.33), and median (IQR) patient averaged pHb was 7.13 (7.07, 7.17). pHb was significantly lower in those who did not survive their hospital stay compared to those that survived. In addition, those with unfavorable neurological outcome had lower pHb values than those with favorable neurological outcome. pHb differentiated between survivors and non-survivors. Measurement of pHb may be a useful indicator of outcome in patients with TBI." @default.
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• W1985604322 date "2004-06-01" @default.
• W1985604322 modified "2023-09-27" @default.
• W1985604322 title "Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury" @default.
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• W1985604322 doi "https://doi.org/10.1089/0897715041269722" @default.
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