FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985604548> ?p ?o ?g. }

• W1985604548 endingPage "131" @default.
• W1985604548 startingPage "122" @default.
• W1985604548 abstract "The great majority of mitochondrial proteins are synthesized by cytosolic ribosomes and then imported into the organelle post-translationally. The translocase of the outer membrane (TOM) is a proteinaceous machinery that contains surface receptors for preprotein recognition and also serves as the main entry gateway into mitochondria. Mitochondrial targeting requires various cytosolic factors, in particular the molecular chaperones Hsc70/Hsp70 and Hsp90. The chaperone activity of Hsc70/Hsp70 and Hsp90 occurs in coordinated cycles of ATP hydrolysis and substrate binding, and is regulated by a number of co-chaperone proteins. The import receptor Tom70 is a member of the tetratricopeptide repeat (TPR) co-chaperone family and contains a conserved TPR clamp domain for interaction with Hsc70 and Hsp90. Such interaction is essential for the initiation of the import process. This review will discuss the roles of Hsc70 and Hsp90 in mitochondrial import and summarize recent progress in understanding these pathways. Keywords: Mitochondria, import, chaperone, Tom70, Hsc70, Hsp90, TOM, ATP hydrolysis, TPR, OM, IM, ATP, Saccharomyces cerevisiae, DNA, GIP, TIM, cytosolic, hydrophobic, hexokinases, DnaK, DnaJ, HPD, DNAJA4, NEF, DNA gyrase B, homodimer, OTC, pmAAT, ANT, AAC, PiC, GA, NB, CiC, OGC, TSPO, Tom71, FKBP38, Cdc37Mitochondria, import, chaperone, Tom70, Hsc70, Hsp90, TOM, ATP hydrolysis, TPR, OM, IM, ATP, Saccharomyces cerevisiae, DNA, GIP, TIM, cytosolic, hydrophobic, hexokinases, DnaK, DnaJ, HPD, DNAJA4, NEF, DNA gyrase B, homodimer, OTC, pmAAT, ANT, AAC, PiC, GA, NB, CiC, OGC, TSPO, Tom71, FKBP38, Cdc37" @default.
• W1985604548 created "2016-06-24" @default.
• W1985604548 creator A5005435563 @default.
• W1985604548 creator A5035598817 @default.
• W1985604548 date "2011-02-01" @default.
• W1985604548 modified "2023-09-25" @default.
• W1985604548 title "Function of Cytosolic Chaperones in Tom70-Mediated Mitochondrial Import" @default.
• W1985604548 cites W1504141563 @default.
• W1985604548 cites W1542766549 @default.
• W1985604548 cites W1577198464 @default.
• W1985604548 cites W1582927527 @default.
• W1985604548 cites W1602112219 @default.
• W1985604548 cites W163606371 @default.
• W1985604548 cites W1689925871 @default.
• W1985604548 cites W1706238475 @default.
• W1985604548 cites W1764690254 @default.
• W1985604548 cites W1955276614 @default.
• W1985604548 cites W1956379070 @default.
• W1985604548 cites W1964892874 @default.
• W1985604548 cites W1965142941 @default.
• W1985604548 cites W1967092231 @default.
• W1985604548 cites W1971393256 @default.
• W1985604548 cites W1974795935 @default.
• W1985604548 cites W1976274224 @default.
• W1985604548 cites W1976358872 @default.
• W1985604548 cites W1978422105 @default.
• W1985604548 cites W1980751552 @default.
• W1985604548 cites W1989074864 @default.
• W1985604548 cites W1989759008 @default.
• W1985604548 cites W1997718936 @default.
• W1985604548 cites W1998456589 @default.
• W1985604548 cites W1999592577 @default.
• W1985604548 cites W2002364392 @default.
• W1985604548 cites W2003708006 @default.
• W1985604548 cites W2005383788 @default.
• W1985604548 cites W2008274778 @default.
• W1985604548 cites W2015588708 @default.
• W1985604548 cites W2022531767 @default.
• W1985604548 cites W2022845257 @default.
• W1985604548 cites W2023034158 @default.
• W1985604548 cites W2025267739 @default.
• W1985604548 cites W2025270890 @default.
• W1985604548 cites W2026314272 @default.
• W1985604548 cites W2032515211 @default.
• W1985604548 cites W2033706352 @default.
• W1985604548 cites W2034943952 @default.
• W1985604548 cites W2034993049 @default.
• W1985604548 cites W2036794157 @default.
• W1985604548 cites W2039386069 @default.
• W1985604548 cites W2040795144 @default.
• W1985604548 cites W2041660879 @default.
• W1985604548 cites W2043693325 @default.
• W1985604548 cites W2044639987 @default.
• W1985604548 cites W2045374621 @default.
• W1985604548 cites W2046044279 @default.
• W1985604548 cites W2046730500 @default.
• W1985604548 cites W2047477750 @default.
• W1985604548 cites W2050005772 @default.
• W1985604548 cites W2050343565 @default.
• W1985604548 cites W2057247659 @default.
• W1985604548 cites W2058872839 @default.
• W1985604548 cites W2062602336 @default.
• W1985604548 cites W2062837921 @default.
• W1985604548 cites W2063420509 @default.
• W1985604548 cites W2063839793 @default.
• W1985604548 cites W2067494371 @default.
• W1985604548 cites W2067511286 @default.
• W1985604548 cites W2067529967 @default.
• W1985604548 cites W2067708969 @default.
• W1985604548 cites W2069816360 @default.
• W1985604548 cites W2070214259 @default.
• W1985604548 cites W2072588550 @default.
• W1985604548 cites W2072744250 @default.
• W1985604548 cites W2072969519 @default.
• W1985604548 cites W2073523633 @default.
• W1985604548 cites W2076945013 @default.
• W1985604548 cites W2077307563 @default.
• W1985604548 cites W2086922403 @default.
• W1985604548 cites W2087125461 @default.
• W1985604548 cites W2087186850 @default.
• W1985604548 cites W2089473305 @default.
• W1985604548 cites W2089882114 @default.
• W1985604548 cites W2090346764 @default.
• W1985604548 cites W2091993153 @default.
• W1985604548 cites W2092198909 @default.
• W1985604548 cites W2101117598 @default.
• W1985604548 cites W2108255072 @default.
• W1985604548 cites W2109936231 @default.
• W1985604548 cites W2112133866 @default.
• W1985604548 cites W2114484640 @default.
• W1985604548 cites W2114965279 @default.
• W1985604548 cites W2115988944 @default.
• W1985604548 cites W2117733546 @default.
• W1985604548 cites W2126909650 @default.
• W1985604548 cites W2128418207 @default.
• W1985604548 cites W2129004089 @default.
• W1985604548 cites W2131630367 @default.
• W1985604548 cites W2136145665 @default.

• next