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- W1985613080 endingPage "871" @default.
- W1985613080 startingPage "841" @default.
- W1985613080 abstract "Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed." @default.
- W1985613080 created "2016-06-24" @default.
- W1985613080 creator A5060391092 @default.
- W1985613080 creator A5082428602 @default.
- W1985613080 date "2011-02-24" @default.
- W1985613080 modified "2023-10-06" @default.
- W1985613080 title "Growth Factor Mediated Signaling in Pancreatic Pathogenesis" @default.
- W1985613080 cites W125686439 @default.
- W1985613080 cites W1480165794 @default.
- W1985613080 cites W1483090589 @default.
- W1985613080 cites W1488156534 @default.
- W1985613080 cites W1513280474 @default.
- W1985613080 cites W1537712767 @default.
- W1985613080 cites W1552575730 @default.
- W1985613080 cites W1580246259 @default.
- W1985613080 cites W1587419561 @default.
- W1985613080 cites W1624346216 @default.
- W1985613080 cites W1871669466 @default.
- W1985613080 cites W1875150791 @default.
- W1985613080 cites W1892096673 @default.
- W1985613080 cites W1965081294 @default.
- W1985613080 cites W1965094170 @default.
- W1985613080 cites W1968855165 @default.
- W1985613080 cites W1970394266 @default.
- W1985613080 cites W1973907258 @default.
- W1985613080 cites W1974165456 @default.
- W1985613080 cites W1977776349 @default.
- W1985613080 cites W1979194001 @default.
- W1985613080 cites W1979627229 @default.
- W1985613080 cites W1981486175 @default.
- W1985613080 cites W1981612052 @default.
- W1985613080 cites W1983763042 @default.
- W1985613080 cites W1985268528 @default.
- W1985613080 cites W1985528986 @default.
- W1985613080 cites W1985712533 @default.
- W1985613080 cites W1985804036 @default.
- W1985613080 cites W1989657978 @default.
- W1985613080 cites W1990814447 @default.
- W1985613080 cites W1992534738 @default.
- W1985613080 cites W1993011693 @default.
- W1985613080 cites W1993312145 @default.
- W1985613080 cites W1994399831 @default.
- W1985613080 cites W1995749507 @default.
- W1985613080 cites W1995785792 @default.
- W1985613080 cites W1996558150 @default.
- W1985613080 cites W2000000541 @default.
- W1985613080 cites W2001213911 @default.
- W1985613080 cites W2002471385 @default.
- W1985613080 cites W2002572032 @default.
- W1985613080 cites W2003445853 @default.
- W1985613080 cites W2003598961 @default.
- W1985613080 cites W2003632139 @default.
- W1985613080 cites W2003639954 @default.
- W1985613080 cites W2004527049 @default.
- W1985613080 cites W2005277488 @default.
- W1985613080 cites W2005492562 @default.
- W1985613080 cites W2007687637 @default.
- W1985613080 cites W2008279940 @default.
- W1985613080 cites W2010092400 @default.
- W1985613080 cites W2010706089 @default.
- W1985613080 cites W2011383859 @default.
- W1985613080 cites W2011540992 @default.
- W1985613080 cites W2011945355 @default.
- W1985613080 cites W2013038209 @default.
- W1985613080 cites W2013965516 @default.
- W1985613080 cites W2015338496 @default.
- W1985613080 cites W2015344488 @default.
- W1985613080 cites W2018190213 @default.
- W1985613080 cites W2018863581 @default.
- W1985613080 cites W2022950801 @default.
- W1985613080 cites W2023560058 @default.
- W1985613080 cites W2024233733 @default.
- W1985613080 cites W2025970479 @default.
- W1985613080 cites W2027526083 @default.
- W1985613080 cites W2028606860 @default.
- W1985613080 cites W2030651159 @default.
- W1985613080 cites W2032499003 @default.
- W1985613080 cites W2032658333 @default.
- W1985613080 cites W2032882287 @default.
- W1985613080 cites W2033351371 @default.
- W1985613080 cites W2034269086 @default.
- W1985613080 cites W2034391789 @default.
- W1985613080 cites W2034646933 @default.
- W1985613080 cites W2037141117 @default.
- W1985613080 cites W2039900769 @default.
- W1985613080 cites W2041687840 @default.
- W1985613080 cites W2041746655 @default.
- W1985613080 cites W2042349690 @default.
- W1985613080 cites W2045498383 @default.
- W1985613080 cites W2048967458 @default.
- W1985613080 cites W2049042095 @default.
- W1985613080 cites W2050987511 @default.
- W1985613080 cites W2055342900 @default.
- W1985613080 cites W2055479791 @default.
- W1985613080 cites W2058528752 @default.
- W1985613080 cites W2059450370 @default.
- W1985613080 cites W2059747609 @default.
- W1985613080 cites W2062473864 @default.