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• W1985613917 endingPage "1747" @default.
• W1985613917 startingPage "1741" @default.
• W1985613917 abstract "The molecules participating in apoptosis induced by T-2 toxin in human leukemia HL-60 cells were investigated. The rank order of the potency of trichothecene mycotoxins to induce internucleosomal DNA fragmentation was found to be T-2, satratoxin G, roridin A >> diacetoxyscirpenol > baccharin B-5 >> nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, fusarenon-X, baccharin B-4=vehicle control. Western blot analysis of caspase-3 in T-2-treated cells clearly indicated the appearance of its catalytically active fragment of 17-kDa. Increased caspase-3 activity was also detected by using a fluorogenic substrate, DEVD-AMC. Next, cells exposed to T-2 led to cleavage of PARP from its native 116-kDa form to the 85-kDa product. Moreover, DFF-45/ICAD were cleaved to give a 12.5-kDa fragment via T-2 treatment. T-2 caused the release of cytochrome c from mitochondria into the cytosol. Increased enzymic activity of caspase-9 on LEHD-AMC was shown. These data indicate that T-2-induced apoptosis involves activation of caspase-3 and DFF-40/CAD through cytosolic accumulation of cytochrome c along with caspase-9 activation." @default.
• W1985613917 created "2016-06-24" @default.
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• W1985613917 date "2001-01-01" @default.
• W1985613917 modified "2023-10-17" @default.
• W1985613917 title "Apoptosis Induction by T-2 Toxin: Activation of Caspase-9, Caspase-3, and DFF-40/CAD through Cytosolic Release of Cytochrome c in HL-60 Cells" @default.
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• W1985613917 doi "https://doi.org/10.1271/bbb.65.1741" @default.
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