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• W1985618339 abstract "Filament based intracellular transport involves the collective action of molecular motor proteins. Experimental evidences suggest that microtubule (MT) filament bound motor proteins such as {it kinesins} weakly interact among themselves during transport and with the surrounding cellular environment. Motivated by these observations we study a driven lattice gas model for collective unidirectional transport of molecular motors on open filament, which incorporates the short-range interactions between the motors on filaments and couples the transport process on filament with surrounding cellular environment through adsorption-desorption Langmuir (LK) kinetics of the motors. We analyse this model within the framework of a Mean Field (MF) theory in the limit of {it weak} interactions between the motors. We point to the mapping of this model with the non-conserved version of Katz-Lebowitz-Spohn (KLS) model. The system exhibits rich phase behavior with variety of inhomogeneous phases including localized shocks in the bulk of the filament. We obtain the steady state density and current profiles and analyse their variation as function of the strength of interaction. We compare these MF results with Monte Carlo simulations and find that the MF analysis shows reasonably good agreement as long as the motors are weakly interacting. We also construct the non-equilibrium MF phase diagram." @default.
• W1985618339 created "2016-06-24" @default.
• W1985618339 creator A5027826957 @default.
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• W1985618339 date "2015-04-01" @default.
• W1985618339 modified "2023-09-28" @default.
• W1985618339 title "Collective transport of weakly interacting molecular motors with Langmuir kinetics" @default.
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• W1985618339 doi "https://doi.org/10.1209/0295-5075/110/18002" @default.
• W1985618339 hasPublicationYear "2015" @default.
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