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- W1985621629 abstract "The filarial protein Abundant Larval Transcript-2 (ALT-2) of the filarial parasite Brugia malayi has been shown to produce 74% worm clearance when administered with an adjuvant. In the present study, we show that it not only induces humoral and cell-mediated immunity, but also protection up to 71% in Mastomys coucha, a permissive animal model for filariasis, even without adjuvant. This unique feature of ALT-2 protein is highly restricted to its 21 amino acid N-terminal signal sequence, the absence of which resulted in poor immune response as well as immunoprotection (49%). Moreover, ALT-2 is likely to exert immunoprotection effects in B. malayi infection by maintaining a Th1–Th2 balance, evident from higher levels of IgG1 and IgG2a as well as IL-4 and IFN-γ. An improved understanding about the role of this filarial protein in host immunity, host–parasite interaction and worm clearance will aid in the development of good immunoprophylaxis for the disease." @default.
- W1985621629 created "2016-06-24" @default.
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- W1985621629 date "2011-11-01" @default.
- W1985621629 modified "2023-09-30" @default.
- W1985621629 title "The adjuvant-free immunoprotection of recombinant filarial protein Abundant Larval Transcript-2 (ALT-2) in Mastomys coucha and the immunoprophylactic importance of its putative signal sequence" @default.
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- W1985621629 doi "https://doi.org/10.1016/j.exppara.2011.08.005" @default.
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