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• W1985642222 abstract "2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH), a free radical-generating azo compound, is gaining prominence as a model oxidant in small molecule and protein therapeutics, namely for its ability to initiate oxidation reactions via both nucleophilic and free radical mechanisms. To better understand its degradation pathways, AAPH was degraded at 40°C in aqueous solutions over a wide pH range. Samples were analyzed via liquid chromatography-ultraviolet spectroscopy and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The thermal decomposition rate of AAPH to form radical species averaged 2.1 × 10(-6) s(-1) and did not vary significantly with pH. The hydrolysis rate increased exponentially with pH, showing hydroxide ion dependence. A mechanism for AAPH hydrolysis is proposed. The LC-MS/MS results provided evidence that the alkoxyl radical is a major radical species in solution. The LC-MS/MS results also showed a radical disproportionation reaction and enabled the generation of an overall reaction scheme showing the various side and termination products of AAPH degradation." @default.
• W1985642222 created "2016-06-24" @default.
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• W1985642222 date "2011-08-01" @default.
• W1985642222 modified "2023-10-11" @default.
• W1985642222 title "Analysis of 2,2’-Azobis (2-Amidinopropane) Dihydrochloride Degradation and Hydrolysis in Aqueous Solutions" @default.
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• W1985642222 doi "https://doi.org/10.1002/jps.22578" @default.
• W1985642222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21560126" @default.
• W1985642222 hasPublicationYear "2011" @default.
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