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- W1985645417 abstract "Active trafficking from the Golgi apparatus is involved in acrosome formation, both by delivering acrosomal contents to the nascent secretory vesicle and by controlling organelle growth and shaping. During murine spermiogenesis, Golgi antigens (giantin, β-COP, golgin 97, mannosidase II) are detected in the acrosome until the late cap-phase spermatids, but are not found in testicular spermatozoa (maturation-phase spermatids). This suggests that Golgi–acrosome flow may be relatively unselective, with Golgi residents retrieved before spermiation is complete. Treatment of spermatogenic cells with brefeldin A, a drug that causes the Golgi apparatus to collapse into the endoplasmic reticulum, disrupted the Golgi in both pachytene spermatocytes and round spermatids. However, this treatment did not affect the acrosomal granule, and some β-COP labeling on the acrosome of elongating spermatids was maintained. Additionally, N-ethylmaleimide sensitive factor, soluble NSF attachment proteins, and homologues of the t-SNARE syntaxin and of the v-SNARE VAMP/synaptobrevin, as well as members of the rab family of small GTPases, are associated with the acrosome (but not the acrosomal granule) in round and elongated spermatids. This suggests that rab proteins and the SNARE machinery for membrane recognition/docking/fusion may be involved in trafficking during mammalian acrosome biogenesis." @default.
- W1985645417 created "2016-06-24" @default.
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- W1985645417 date "2001-07-01" @default.
- W1985645417 modified "2023-10-18" @default.
- W1985645417 title "Membrane Trafficking Machinery Components Associated with the Mammalian Acrosome during Spermiogenesis" @default.
- W1985645417 cites W142190260 @default.
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- W1985645417 cites W1881270362 @default.
- W1985645417 cites W1966516246 @default.
- W1985645417 cites W1968784370 @default.
- W1985645417 cites W1975425719 @default.
- W1985645417 cites W1978701884 @default.
- W1985645417 cites W1980226278 @default.
- W1985645417 cites W1983359790 @default.
- W1985645417 cites W1987219070 @default.
- W1985645417 cites W1991176695 @default.
- W1985645417 cites W1992337674 @default.
- W1985645417 cites W1992507201 @default.
- W1985645417 cites W1995592727 @default.
- W1985645417 cites W2003037982 @default.
- W1985645417 cites W2004232473 @default.
- W1985645417 cites W2008475447 @default.
- W1985645417 cites W2016266703 @default.
- W1985645417 cites W2018650543 @default.
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- W1985645417 cites W2024767760 @default.
- W1985645417 cites W2025724784 @default.
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- W1985645417 cites W2034281339 @default.
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- W1985645417 cites W2036174328 @default.
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- W1985645417 cites W2067722891 @default.
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- W1985645417 cites W2076386900 @default.
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- W1985645417 cites W2146217243 @default.
- W1985645417 cites W2147173605 @default.
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- W1985645417 doi "https://doi.org/10.1006/excr.2000.5119" @default.
- W1985645417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11412037" @default.
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