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- W1985647583 abstract "Abstract Mouse plasmacytoma MOPC-315 produces light and heavy immunoglobulin chains. The variants, MOPC-315 NP-1 and MOPC-315 NR, synthesize only heavy or light chains, respectively. To eludicate the inability of MOPC-315 variants to produce intact light or heavy chains, complementary DNAs (cDNAs) to the mRNAs were prepared. From the kinetics of DNA-RNA hybridization, the RNA of the MOPC-315 NP-1 variant was shown to contain few or no sequences homologous with MOPC-315 light chain mRNA. Thus, the inability of this variant to produce light chain results from the absence of light chain mRNA. In contrast, the polyadenylated mRNA fraction of the MOPC-315 NR variant, which does not synthesize heavy chain, contains about two-thirds of the sequences present in heavy chain mRNA. Thus, this variant contains a fragment of heavy chain mRNA." @default.
- W1985647583 created "2016-06-24" @default.
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- W1985647583 date "1978-05-01" @default.
- W1985647583 modified "2023-10-16" @default.
- W1985647583 title "Messenger RNA for immunoglobulin light and heavy chains in MOPC-315 plasmacytoma and variants" @default.
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- W1985647583 doi "https://doi.org/10.1016/0003-9861(78)90361-2" @default.
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