FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985652307> ?p ?o ?g. }

• W1985652307 endingPage "950" @default.
• W1985652307 startingPage "943" @default.
• W1985652307 abstract "Abstract The radiation-induced bystander effect represents a paradigm shift in our understanding of the radiobiological effects of ionizing radiation, in that extranuclear and extracellular events may also contribute to the final biological consequences of exposure to low doses of radiation. Although radiation-induced bystander effects have been well documented in a variety of biological systems, the mechanism is not known. It is likely that multiple pathways are involved in the bystander phenomenon, and different cell types respond differently to bystander signalling. Using cDNA microarrays, a number of cellular signalling genes, including cyclooxygenase-2 (COX-2), have been shown to be causally linked to the bystander phenomenon. The observation that inhibition of the phosphorylation of extracellular signal-related kinase (ERK) suppressed the bystander response further confirmed the important role of the mitogen-activated protein kinase (MAPK) signalling cascade in the bystander process. Furthermore, cells deficient in mitochondrial DNA showed a significantly reduced response to bystander signalling, suggesting a functional role of mitochondria in the signalling process. Inhibitors of nitric oxide (NO) synthase (NOS) and mitochondrial calcium uptake provided evidence that NO and calcium signalling are part of the signalling cascade. The bystander observations imply that the relevant target for various radiobiological endpoints is larger than an individual cell. A better understanding of the cellular and molecular mechanisms of the bystander phenomenon, together with evidence of their occurrence in-vivo, will allow us to formulate a more accurate model for assessing the health effects of low doses of ionizing radiation." @default.
• W1985652307 created "2016-06-24" @default.
• W1985652307 creator A5009696243 @default.
• W1985652307 creator A5013984522 @default.
• W1985652307 creator A5014439886 @default.
• W1985652307 creator A5039752024 @default.
• W1985652307 creator A5048201953 @default.
• W1985652307 creator A5067197557 @default.
• W1985652307 creator A5077165024 @default.
• W1985652307 creator A5091297456 @default.
• W1985652307 date "2008-08-01" @default.
• W1985652307 modified "2023-10-03" @default.
• W1985652307 title "Mechanism of radiation-induced bystander effects: a unifying model" @default.
• W1985652307 cites W1509216925 @default.
• W1985652307 cites W1845118669 @default.
• W1985652307 cites W1970579593 @default.
• W1985652307 cites W1976907974 @default.
• W1985652307 cites W1977532213 @default.
• W1985652307 cites W1981797176 @default.
• W1985652307 cites W1991562853 @default.
• W1985652307 cites W2003811750 @default.
• W1985652307 cites W2003958312 @default.
• W1985652307 cites W2021551701 @default.
• W1985652307 cites W2027262563 @default.
• W1985652307 cites W2032863233 @default.
• W1985652307 cites W2039370168 @default.
• W1985652307 cites W2048822811 @default.
• W1985652307 cites W2053571737 @default.
• W1985652307 cites W2054749775 @default.
• W1985652307 cites W2060057454 @default.
• W1985652307 cites W2081401746 @default.
• W1985652307 cites W2081642488 @default.
• W1985652307 cites W2090348952 @default.
• W1985652307 cites W2094066863 @default.
• W1985652307 cites W2096775962 @default.
• W1985652307 cites W2097608062 @default.
• W1985652307 cites W2101245011 @default.
• W1985652307 cites W2102433483 @default.
• W1985652307 cites W2108334898 @default.
• W1985652307 cites W2110928379 @default.
• W1985652307 cites W2115297036 @default.
• W1985652307 cites W2119065274 @default.
• W1985652307 cites W2129903518 @default.
• W1985652307 cites W2132305988 @default.
• W1985652307 cites W2148020513 @default.
• W1985652307 cites W2153080177 @default.
• W1985652307 cites W2155377609 @default.
• W1985652307 cites W2159886619 @default.
• W1985652307 cites W2167894711 @default.
• W1985652307 cites W2171476116 @default.
• W1985652307 cites W2177155101 @default.
• W1985652307 cites W2257496989 @default.
• W1985652307 cites W2315613727 @default.
• W1985652307 cites W2335415058 @default.
• W1985652307 doi "https://doi.org/10.1211/jpp.60.8.0001" @default.
• W1985652307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4410683" @default.
• W1985652307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18644187" @default.
• W1985652307 hasPublicationYear "2008" @default.
• W1985652307 type Work @default.
• W1985652307 sameAs 1985652307 @default.
• W1985652307 citedByCount "288" @default.
• W1985652307 countsByYear W19856523072012 @default.
• W1985652307 countsByYear W19856523072013 @default.
• W1985652307 countsByYear W19856523072014 @default.
• W1985652307 countsByYear W19856523072015 @default.
• W1985652307 countsByYear W19856523072016 @default.
• W1985652307 countsByYear W19856523072017 @default.
• W1985652307 countsByYear W19856523072018 @default.
• W1985652307 countsByYear W19856523072019 @default.
• W1985652307 countsByYear W19856523072020 @default.
• W1985652307 countsByYear W19856523072021 @default.
• W1985652307 countsByYear W19856523072022 @default.
• W1985652307 countsByYear W19856523072023 @default.
• W1985652307 crossrefType "journal-article" @default.
• W1985652307 hasAuthorship W1985652307A5009696243 @default.
• W1985652307 hasAuthorship W1985652307A5013984522 @default.
• W1985652307 hasAuthorship W1985652307A5014439886 @default.
• W1985652307 hasAuthorship W1985652307A5039752024 @default.
• W1985652307 hasAuthorship W1985652307A5048201953 @default.
• W1985652307 hasAuthorship W1985652307A5067197557 @default.
• W1985652307 hasAuthorship W1985652307A5077165024 @default.
• W1985652307 hasAuthorship W1985652307A5091297456 @default.
• W1985652307 hasBestOaLocation W19856523071 @default.
• W1985652307 hasConcept C111472728 @default.
• W1985652307 hasConcept C138885662 @default.
• W1985652307 hasConcept C184235292 @default.
• W1985652307 hasConcept C19106626 @default.
• W1985652307 hasConcept C201571599 @default.
• W1985652307 hasConcept C203014093 @default.
• W1985652307 hasConcept C28859421 @default.
• W1985652307 hasConcept C57074206 @default.
• W1985652307 hasConcept C62478195 @default.
• W1985652307 hasConcept C86803240 @default.
• W1985652307 hasConcept C89611455 @default.
• W1985652307 hasConcept C95444343 @default.
• W1985652307 hasConceptScore W1985652307C111472728 @default.
• W1985652307 hasConceptScore W1985652307C138885662 @default.
• W1985652307 hasConceptScore W1985652307C184235292 @default.

• next