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- W1985652952 abstract "Abstract The influence of p-chlorophenylalanine, pargyline, reserpine and α-methyltyrosine upon the development of acute tolerance to and dependence on morphine in the respiratory centre, was studied in decerebrate cats. Resting and CO2-stimulated respiration were evaluated. p-CPA did not inhibit either tolerance or dependence, but it rather facilitated the development of tolerance and did not modify the abstinence syndrome elicited by naloxone. Tolerance was partially inhibited by pargyline, and was not modified by reserpine. α-MT delayed the appearance of tolerance and depressed the manifestation of dependence. The results emphasize the synergic interaction between morphine and serotonin, and suggest a modulatory role for the central noradrenergic system on the development of tolerance and dependence." @default.
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- W1985652952 date "1973-04-01" @default.
- W1985652952 modified "2023-09-23" @default.
- W1985652952 title "Brain amines and development of acute tolerance to and dependence on morphine in the respiratory center of decerebrate cats" @default.
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- W1985652952 doi "https://doi.org/10.1016/0028-3908(73)90095-6" @default.
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